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- Aminopyridine refer to
following chemical compounds: 2-Aminopyridine, 3-Aminopyridine ,
- An organic compound with
the chemical formula C5H4N–NH2. The molecule is one of the three
isomeric amines of pyridine.
- 4-Aminopyridine (4-AP) is
a voltage-gated, fast potassium channel blocker capable of improving
axonal conduction by facilitating the propagation of action potentials
in demyelinated nerve fibers.
- Prepared by the
decarbonylation of pyridine-4-carboxamide using sodium hypochlorite.
- It is used primarily as a
research tool, in characterizing subtypes of potassium channel, and has
also been used to manage some of the symptoms of multiple sclerosis.
- 4-AP is sold under the
trade name Avitrol as .5% or 1% in bird control bait.
- 2-Aminopyridine is an
organic compound with the formula H2NC5H4N. It is one of three isomeric
- It is a colourless solid
that is used in the production of the drugs piroxicam, sulfapyridine,
tenoxicam, and tripelennamine. It is produced by the reaction of sodium
amide with pyridine, the Chichibabin reaction.
derivatives are obtained by reacting a quaternary ammonium compound with
malodinitrile in the presence of an alkanol, followed with ammonia,
water and ether to give aminonicotinonitrile and then reacting this
product with an alkali metal compound to give
- A potassium channel
blocker, is capable of restoring conduction in the injured spinal cord
and also employed mostly clinically.
- In the symptomatic
treatment of multiple sclerosis, acts by improving nerve conduction even
in the presence of myelin damage. It is used as a research tool to
characterize potassium channel subtypes.
- 2-AP derivatives produced
are valuable starting materials for the preparation of pesticides,
drugs, vitamins and dyes.
- Anthraquinone based acid
with 2-AP dyes have found application in dyeing wool polyamide
- Invention relates to HSP90
inhibitors containing fused amino pyridine core that are
useful as inhibitors which used in the treatment of HSP90 related
diseases and disorders such as cancer or a neurodegenerative disease.
- A pharmaceutical
composition contains a therapeutically amount of a aminopyridine
dispersed in a release matrix, for example a composition that can be
formulated into a stable, sustained-release oral dosage formulation,
such as tablet.
- Usage of aminopyridine
compounds extends to treat peripheral nervous system
demyelinating diseases includes diabetes mellitus, Guillain-Barre
- Dependent upon the
membrane potential, Aminopyridines selectively block K channels of squid
axon membranes and the duration and frequency of voltage clamp pulses.
They are effective when applied to either the internal or the external
- The steady-state block of
K channels by aminopyridine is more complete for low depolarizations and
is gradually relieved at higher depolarizations.
- 3-AP is used as an
intermediate in the production of pharmaceuticals, agrochemicals and
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