Aminopyridine

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  • Aminopyridine refer to following chemical compounds: 2-Aminopyridine, 3-Aminopyridine , 4-Aminopyridine.
  • An organic compound with the chemical formula C5H4NNH2. The molecule is one of the three isomeric amines of pyridine.
  • 4-Aminopyridine (4-AP) is a voltage-gated, fast potassium channel blocker capable of improving axonal conduction by facilitating the propagation of action potentials in demyelinated nerve fibers.
  • Prepared by the decarbonylation of pyridine-4-carboxamide using sodium hypochlorite.
  • It is used primarily as a research tool, in characterizing subtypes of potassium channel, and has also been used to manage some of the symptoms of multiple sclerosis.
  • 4-AP is sold under the trade name Avitrol as .5% or 1% in bird control bait.
  • 2-Aminopyridine is an organic compound with the formula H2NC5H4N. It is one of three isomeric Aminopyridines.
  • It is a colourless solid that is used in the production of the drugs piroxicam, sulfapyridine, tenoxicam, and tripelennamine. It is produced by the reaction of sodium amide with pyridine, the Chichibabin reaction.
  • 2-Aminopyridine derivatives are obtained by reacting a quaternary ammonium compound with malodinitrile in the presence of an alkanol, followed with ammonia, water and ether to give aminonicotinonitrile and then reacting this product with an alkali metal compound to give
    aminonicotinic acid.
  • A potassium channel blocker, is capable of restoring conduction in the injured spinal cord and also employed mostly clinically.
  • In the symptomatic treatment of multiple sclerosis, acts by improving nerve conduction even in the presence of myelin damage. It is used as a research tool to characterize potassium channel subtypes.
  • 2-AP derivatives produced are valuable starting materials for the preparation of pesticides, drugs, vitamins and dyes.
  • Anthraquinone based acid with 2-AP dyes have found  application in dyeing wool polyamide fibers.
  • Invention relates to HSP90 inhibitors containing fused amino pyridine core that are
    useful as inhibitors which used in the treatment of HSP90 related diseases and disorders such as cancer or a neurodegenerative disease.
  • A pharmaceutical composition contains a therapeutically amount of a aminopyridine dispersed in a release matrix, for example a composition that can be formulated into a stable, sustained-release oral dosage formulation, such as tablet.
  • Usage of aminopyridine compounds extends to treat peripheral nervous system
    demyelinating diseases includes diabetes mellitus, Guillain-Barre Syndrome.
  • Dependent upon the membrane potential, Aminopyridines selectively block K channels of squid axon membranes and the duration and frequency of voltage clamp pulses. They are effective when applied to either the internal or the external membrane surface.
  • The steady-state block of K channels by aminopyridine is more complete for low depolarizations and is gradually relieved at higher depolarizations.
  • 3-AP is used as an intermediate in the production of pharmaceuticals, agrochemicals and dyes.

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