antipyretic is a type of medication that will prevent or reduce
fever by lowering body temperature from a raised state.
- They will
not affect normal body temperature if the patient does not have a
most non-steroidal anti-inflammatory drugs (NSAIDs) work by
inhibiting prostaglandin synthetase within the hypothalamus.
Acetaminophen and ibuprofen are currently the most frequently used
antipyretic medications in children due to their safety and
alternating acetaminophen with ibuprofen has become commonplace by
both parents and physicians.
- At a
national meeting, 50% of pediatricians reported that they routinely
advised parents to alternate acetaminophen with ibuprofen.
Antipyretics work by getting the "thermostat" in the hypothalamus to
override the interleukin-induced increase in temperature.
- The body
will then work to lower the temperature to the new, lower
temperature and the result is a reduction in the fever.
Antipyretics will also reduce prostaglandin synthesis in the
hypothalamus by inhibiting the effect of endogenous or microbial
pyrogens on the heat regulating sensors of the hypothalamus.
blocking prostaglandin synthetase, antipyretics prevent a rise in
prostaglandin levels in the brain.
drugs include aspirin, acetaminophen , ibuprofen , naproxen ,
, and narcotic drugs including morphine, oxycodone,
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