has previously been suggested to rapidly reverse alloxan diabetes in
We have assessed the therapeutic value of the compound in two further
animal models of insulin-dependent diabetes mellitus, namely
streptozotocin-diabetic rats and the spontaneously diabetic BB/E rat.
There was no
indication of areversal of established diabetes in either the
streptozotocin-diabetic or the spontaneously diabetic BB/E rats.
epicatechin also failed to halt the progression of the disease in
prediabetic BB/E rats. Earlier claims of the potential use of
epicatechin as an antidiabetic agent must therefore be treated with some
been used that resolve stereoisomers of epicatechin and catechin. In
beans harvested from unripe and ripe cacao pods, we find only (-)-epicatechin
and (+)-catechin with (-)-epicatechin being by far the predominant
When beans are
fermented there is a large loss of both (-)-epicatechin and (+)-catechin,
but also the formation of (-)-catechin.We hypothesize that the heat of
fermentation may, in part, be responsible for the formation of this
When beans are
progressively roasted at conditions described as low, medium and high
roast conditions, there is a progressive loss epicatechin and (+)-catechin
and an increase in (-)-catechin with the higher roast levels.
and Dutch-processed cacao powders are analyzed, there is progressive
loss of both epicatechin and (+)-catechin with lesser losses of catechin.
observe that in even lightly Dutch-processed powder, the level of (-)-catechin
exceeds the level of (-)-epicatechin.
results indicate that much of the increase in the level of (-)-catechin
observed during various processing steps may be the result of
heat-related epimerization from epicatechin.
Epicatechin effects would be beneficial in supporting the management of
secondary complications of diabetes. Polyphenols were shown to be useful
in the long term preservation of rat pancreatic islets in vitro under
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