- Folate, a
water-soluble vitamin, helps the body form red blood cells and aids
in the formation of genetic material within every body cell.
deficiency is a lack of folic acid in the diet and the signs are
- Folate, an
important B-group vitamin, participates in many metabolic pathways
such as DNA and RNA biosynthesis and amino acid inter-conversions.
proliferating cells require large amounts of folate to support
efficient DNA replication, repair and methylation indicating the
importance of folate in human metabolism.
- Folate is an
essential cofactor during human erythropoiesis. Low folate levels
lead to prolongation of the synthesis phase of cell division and
retardation of germ cell maturation.
bacteria, mostly belonging to the genera Lactobacillus and
Bifidobacterium, confer a number of health benefits to the host,
including vitamin production.
plantarum constitutes an exception among lactobacilli, since it is
capable of folate production in presence of para-aminobenzoic acid (pABA)
and deserves to be used in animal trials to validate its ability to
produce the vitamin in vivo.
- It is
commonly recognized that folates may play a role in the prevention
of cardiovascular disease by reducing the homocysteine
concentrations in the blood.
auxotrophic organisms, such as humans, contain a polyglutamyl folate
hydrolase activity to remove the glutamyl tail and make the folate
available for uptake by the tissue cells. This conversion is
catalyzed by intestinal ?-glutamyl hydrolases.
- Recent data
indicate that the folate status in the USA population has improved
significantly, presumably due to the effects of fortification.
- The highest
folate concentrations were mostly found in color-fleshed potatoes.
Variations of folate concentrations within either color- or
white-fleshed tubers were similar ( 2-fold). Skin contained 30%
higher folate concentrations than flesh.
- Storage of
tubers for 7 months generally led to an increase in folate contents.
Semiquantitative RT-PCR analyses showed that higher folate contents
were correlated with lower mRNA expression of some folate genes.
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