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  • Labetalol Hydrochloride is an adrenergic receptor blocking agent that has both selective alpha1- and nonselective beta-adrenergic receptor blocking actions in a single substance.
  • Labetalol Hydrochloride is a racemate, chemically designated as 5-[1-hydroxy-2-[(1-methyl-3-phenylpropyl) amino] ethyl] salicylamide monohydrochloride.
  • Labetalol (Normodyne, Trandate, fixed combination with hydrochlorothiazide: Normozyde) is a mixed alpha/beta adrenergic
    antagonist, which is used to treat high blood pressure.
  • Labetalol HCl is a white or off-white crystalline powder, soluble in water.
  • Labetalol Hydrochloride Injection is used to lower high blood pressure, also called hypertension.
  • Labetalol Hydrochloride has a particular indication in the treatment of pregnancy-induced hypertension which is commonly associated with pre-eclampsia.
  • Labetalol Hydrochloride is also used to treat chronic and acute hypertension of pheochromocytoma and hypertensive crisis.
  • Labetalol blocks beta receptors that are found in the heart. This reduces the action of adrenaline and noradrenaline on the heart, causing it to beat more slowly and with less force. In turn, this reduces the pressure at which the blood is pumped out of the heart and around the body, which helps to reduce blood pressure.
  • Labetalol's action in slowing the rate and force of the heartbeat also reduces the energy used by the heart to pump blood
    around the body. This reduces the heart's need for oxygen, which means that labetalol can also be used in the management of  angina. Angina is chest pain that occurs because the heart does not get enough oxygen to meet demand, for example during exercise.
  • Labetalol HCl Injection is contraindicated in bronchial asthma, overt cardiac failure, greater than first degree heart block, cardiogenic shock, severe bradycardia, other conditions associated with severe and prolonged hypotension.
  • Labetalol is considered a pregnancy Category C medicine by the U.S. Food and Drug Administration (FDA), which means that it might not be safe for use during pregnancy, although the full risks are currently unknown.
  • Labetalol was quicker and more efficient at controlling blood pressure, having a beneficial effect on renal functions and causing fewer side effects compared with methyldopa.

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