their derivatives are used in the manufacture of dyes; β-naphthol methyl
ether and β-naphthol ethyl ether (neroli oil) are used in cosmetics
manufacture for the preparation of soap perfumes
are true cold water dyes since many of the components used in naphthol
dyeing are known or suspected carcinogens, they should not be used in
α-naphthol, is a colorless crystalline solid with the formula c10h7oh.
It is an
isomer of 2-naphthol differing by the location of the hydroxyl group on
naphthalene the naphthols are naphthalene homologues of phenol, with the
hydroxyl group being more reactive than in the phenols.
are soluble in simple alcohols, ethers, and chloroform. they can be used
in the production of dyes and in organic synthesis.
and other celluosic fibers, as well as silk, can also be dyed with azoic
or naphthol dyes naphthol is sometimes also spelled as 'napthol' or
'naphtol' the latter is the German spelling.
They should be
used only in a lab, or in a dye studio in which good laboratory
practices are invariably followed
Naphthol is an
alcohol derived from naphthalene (C10H8), which is obtained from
coal-tar in the form of white shining crystals of a strong, disagreeable
odor, soluble in alcohol, but insoluble in water, and employed locally
in indolent ulcers and as a disinfectant in pus-pockets and wounds and
has recently been shown to be selectively toxic to short-term organ
cultures of human colorectal tumor tissue.
underlying 1-naphthol's selective toxicity is as yet unknown
be due to the formation naphthoquinone metabolites, which are known to
be highly toxic to tumor cells. by using high-performance liquid
chromatography with reductive electrochemical detection, it has been
possible to show that 1-naphthol is converted to naphthoquinone
metabolites by rat liver microsomes.
At least two
metabolic pathways, independent of cytochrome P-450, appear to be
lipid peroxidation appears to be responsible for at least part of the
conversion of 1-naphthol topredominantly 1,4-naphthoquinone, and it
superoxide anion radical generation by nadph-cytochrome P-450 reductase
could also catalyze this conversion.
Workers in tar
distillation and naphthalene distillation are exposed to rather low
concentrations of naphthalene and methylated naphthalenes and naphthols.
1,4-naphthoquinone identified in the urine appear to be the products of
hydroxylation of naphthalene present in the breathing-zone air.
findings suggest that the summary concentration of naphthols in urine
can be used as a biomarker for naphthalene exposures
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