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  • Niacinamide (Vitamin B3) is utilized in numerous topical cosmetic products to provide beneficial effects for a wide array of common skin problems such as those associated with aging and photo aging, e.g., dryness, red blotchiness, hyper pigmentation, texture problems and fine lines/wrinkles .
  • A general mechanism for niacinamide is as a precursor to the important cofactors nicotinamide adenine dinucleotide (NAD), its phosphate derivative (NADP), and their reduced forms (NADH and NADPH).
  • Large pharmacological doses of niacinamide were effective in relieving the symptoms of anxiety.
  • Niacinamide reduced lipogenesis in a dose-dependent manner, with significant inhibitory
    activity observed up to 4.0% (w/v) niacinamide.
  • For example, at 1% niacinamide lipogenesis was significantly reduced to 33% of control levels.
  • Niacinamide has other possible biochemical properties (corrects sub clinical pellagra, corrects vitamin B3 dependency, and favorably modulates blood lactate) that may perhaps make it a more effective agent than current contemporary medications for the treatment of anxiety disorders.
  • Anti-inflammatory action affecting neutrophil chemotaxis has been reported for niacinamide.
  • Additionally, due to its inhibition of ADP-ribosylation, niacinamide has been shown to suppress cytokinemediated induction of nitric oxide synthase in a number of cells, thus effecting interleukin-1-exposed chondrocytes, resulting in decreased inflammation.
  • Niacinamide inhibits free radical formation and facilitates beta-cell regeneration in vivo and in vitro.
  • Nicotinamide has been reported to increase the endurance of mice.
  • Biochemical data showing niacinamide to have both benzodiazepine-like properties and the ability to increase serotonin synthesis.

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