Niacinamide (Vitamin B3) is utilized in numerous topical cosmetic
products to provide beneficial effects for a wide array of common skin
problems such as those associated with aging and photo aging, e.g.,
dryness, red blotchiness, hyper pigmentation, texture problems and fine
A general mechanism for niacinamide is as a precursor to the important
cofactors nicotinamide adenine dinucleotide (NAD), its phosphate
derivative (NADP), and their reduced forms (NADH and NADPH).
Large pharmacological doses of niacinamide were effective in relieving
the symptoms of anxiety.
Niacinamide reduced lipogenesis in a dose-dependent manner, with
activity observed up to 4.0% (w/v) niacinamide.
For example, at 1% niacinamide
lipogenesis was significantly reduced to 33% of control levels.
Niacinamide has other possible biochemical properties (corrects
sub clinical pellagra, corrects vitamin B3 dependency, and favorably
modulates blood lactate) that may perhaps make it a more
effective agent than current contemporary medications for the treatment
Anti-inflammatory action affecting neutrophil chemotaxis has been
reported for niacinamide.
Additionally, due to its inhibition of ADP-ribosylation, niacinamide
has been shown to suppress cytokinemediated induction of nitric
oxide synthase in a number of cells, thus effecting
interleukin-1-exposed chondrocytes, resulting in decreased
Niacinamide inhibits free radical formation and facilitates
beta-cell regeneration in vivo
and in vitro.
Nicotinamide has been reported to increase the endurance of mice.
Biochemical data showing niacinamide to have both
benzodiazepine-like properties and the ability to increase serotonin
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