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  • Octamethylcyclotetrasiloxane (D4) is an odorless, colorless non-oily silicone fluid used primarily to make other silicone materials.

  • During this manufacturing process, virtually all of the material is consumed, with only a tiny amount of D4 remaining.

  •  In a small handful of personal care products,D4 can be used as an additive providing certain   application-related benefits preferred by consumers.

  • Cyclic dimethylsiloxane tetramer D4 tetracyclomethicone, siloxane ,octamethylcyclotetra siloxanes and Silicones octamethylcyclotetra Siloxanes octamethylcyclotetra-octamethylcyclotetrasiloxane octamethylcyclotetrasiloxane, cyclo(octamethyl)tetrasiloxane

  • Octamethylcyclotetrasiloxane (OMCTS), a common constituent of household products, triggers the transformation of bismuth to the volatile toxic derivative trimethylbismuth by methanosarcina barkeri which is a representative member of the sewage sludge microflora.

  • Comparative studies with the ionophores monensin and lasalocid,induce effects similar to those observed for indicated that the stimulation of bismuth methylation is not specific for the siloxane and suggested that the stimulation observed is mainly due to facilitated membrane permeation of the metal ion

  • The cyclic siloxane octamethylcyclotetrasiloxane and the linear siloxane hexamethyldisiloxane have numerous industrial and consumer applications and thus have the potential for human exposure.

  • The present study was undertaken to examine potential estrogenic and antiestrogenic activities of D4 and HMDS

  • Octamethylcyclotetrasiloxane or D4 is a low molecular weight siloxane (LMWS) fluid with a low surface tension, low aqueous solubility, high lipid solubility, and low vapor pressure

  • It is present at 40-60% by weight in personal care products such as antiperspirants, cosmetics, and hair care products

  • Because of its widespread use in these products, a typical woman is exposed to an average daily intake (ADI) of 0.158 mg/kg/day (11.1 mg/day) of D4 from daily use of such products bioavailability, breast implant, D4, implantation, inhalation octamethylcyclotetrasiloxane, PBPK, physiologically based pharmacokinetic model, risk assessment, silicone

  • Synthetic silicon-containing compounds (silicones) are use din a variety of consumer products, e.g., skin care products, antiperspirants, antacids, and antiflatulence agents

  • Octamethylcyclotetrasiloxane is a base fluid in a number of personal care products, with excellent spreading and lubrication properties and unique volatility characteristics.

  • Octamethylcyclotetrasiloxane can be used in bath oils, deodorants, skin creams, lotions, suntan and shaving products, nail polishes.

  • Octamethylcyclotetrasiloxane has faster drying time in low voc formulate in hair sprays

  • There is potential for human exposure to cyclic siloxanes by the respiratory route.

  • To determine the pharmacokinetics of octamethylcyclotetrasiloxane (D4), a material commonly found in personal care products, the respiratory intake and uptake of D4 were measured in 12 healthy volunteers on two occasions.

  • The deposition in continuous wave (cw) mode was compared with pulsed conditions
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