Octamethylcyclotetrasiloxane (D4) is an odorless, colorless non-oily
silicone fluid used primarily to make other silicone materials.
manufacturing process, virtually all of the material is consumed, with
only a tiny amount of D4 remaining.
In a small
handful of personal care products,D4 can be used as an additive
providing certain application-related benefits preferred by
dimethylsiloxane tetramer D4 tetracyclomethicone, siloxane
,octamethylcyclotetra siloxanes and Silicones octamethylcyclotetra
Octamethylcyclotetrasiloxane (OMCTS), a common constituent of household
products, triggers the transformation of bismuth to the volatile toxic
derivative trimethylbismuth by methanosarcina barkeri which is a
representative member of the sewage sludge microflora.
studies with the ionophores monensin and lasalocid,induce effects
similar to those observed for indicated that the stimulation of bismuth
methylation is not specific for the siloxane and suggested that the
stimulation observed is mainly due to facilitated membrane permeation of
the metal ion
siloxane octamethylcyclotetrasiloxane and the linear siloxane
hexamethyldisiloxane have numerous industrial and consumer applications
and thus have the potential for human exposure.
study was undertaken to examine potential estrogenic and antiestrogenic
activities of D4 and HMDS
Octamethylcyclotetrasiloxane or D4 is a low molecular weight siloxane
(LMWS) fluid with a low surface tension, low aqueous solubility, high
lipid solubility, and low vapor pressure
It is present
at 40-60% by weight in personal care products such as antiperspirants,
cosmetics, and hair care products
Because of its
widespread use in these products, a typical woman is exposed to an
average daily intake (ADI) of 0.158 mg/kg/day (11.1 mg/day) of D4 from
daily use of such products bioavailability, breast implant, D4,
implantation, inhalation octamethylcyclotetrasiloxane, PBPK,
physiologically based pharmacokinetic model, risk assessment, silicone
silicon-containing compounds (silicones) are use din a variety of
consumer products, e.g., skin care products, antiperspirants, antacids,
and antiflatulence agents
Octamethylcyclotetrasiloxane is a base fluid in a number of personal
care products, with excellent spreading and lubrication properties and
unique volatility characteristics.
Octamethylcyclotetrasiloxane can be used in bath oils, deodorants, skin
creams, lotions, suntan and shaving products, nail polishes.
Octamethylcyclotetrasiloxane has faster drying time in low voc formulate
in hair sprays
potential for human exposure to cyclic siloxanes by the respiratory
the pharmacokinetics of octamethylcyclotetrasiloxane (D4), a material
commonly found in personal care products, the respiratory intake and
uptake of D4 were measured in 12 healthy volunteers on two occasions.
deposition in continuous wave (cw) mode was compared with pulsed
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