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Pharmaceutical Film coating

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Information @ a Glance

  • The coating of solid pharmaceutical dosage forms began in the ninth century B.C., with the Egyptians.
  • At that time the primary solid dosage form was the pill, a hand-shaped spherical mass containing drug, sugar, and other diluents. A variety of materials were used to coat pills, such as talc, gelatin, and sugar.
  • Gold and silver were also used.
  • The candy-making industry was the first to develop and enhance the art of coating. It is most likely that the pharmaceutical industry adopted sugar coating technology for its own use.
  • The first sugar-coated pills produced in the United States came out of Philadelphia in 1856.
  • Coatings resistant to enteric or gastric fluids were developed in the 1880s. In 1953 the first compression-coated tablet was introduced, and in 1954 the first film-coated tablet was marketed.
  • There are many reasons for coating tablets; some aesthetic, some functional.
  • One important reason is to enhance drug stability; that is, to protect the drug from oxygen, moisture, and light, the three key causes of drug degradation. Coating can also be used to separate reactive components in a tablet formula. Another important reason for tablet coating is identification.
  • Tablet coatings may take on a variety of colors. A coated tablet may also be imprinted with a symbol or word. In the case of the film-coated tablet, the tablet core may be embossed with a symbol or word that remains visible after the coating process.
  • The coating is used to uniquely identify a branded product.
  • Tablet coating is done for aesthetic reasons as well. Often the appearance of the tablet core is mottled or otherwise unattractive. Coating masks this. Many times, too, the drug itself has a bitter taste.
  • Coating masks this as well. Tablet coating can also be used to control the duration and site of drug release. Overall, tablet  coating, through an additional step in the manufacturing process, is often vital.
  • Tablet coating is perhaps one of the oldest pharmaceutical processes still in existence.
  • A film coating is a thin polymer-based coat applied to a solid dosage form such as a tablet, granule or other particle.
  • The thickness of such a coating is usually between 20 and 100 μm. Under close examination the film structure.
  • To maximize the efficiency of the coating application process, high-solids loadings are desirable. By reducing the coating time using high-solids formulations, productivity is increased and overall manufacturing costs are reduced.
  • Aquarius Preferred film coating systems are state-of-the-art immediate-release coatings, which have been scientifically formulated with careful polymer selection.
  • Clear advantages in film coating process productivity are seen with high-solids suspensions.
  • The coating system to be increased significantly with viscosities in the range of 100300 cP.
     

 

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