- Salbutamol is an
inhaled medication commonly used in quick-relief inhalers and
- People with asthma
and chronic obstructive pulmonary disease (COPD) are often
prescribed salbutamol to help control their disease.
- Salbutamol working by
opening up the lungs and helping you to breathe when you are having
an asthma attack or other difficulty breathing.
- This medicine is also
useful for the prevention of exercise-induced bronchospasm, as well
as indicated in hyperkalemia, especially in patients with renal
- Salbutamol is
typically used to treat bronchospasm (due to either asthma or
exercise) as well as chronic obstructive pulmonary disease.
- Other uses include in
cystic fibrosis, along with ipratropium bromide, acetylcysteine, and
pulmozyme and subtypes of congenital myasthenic syndromes associated
to mutations in Dok-7.
- As a β2-agonist,
salbutamol also finds use in obstetrics. Intravenous salbutamol can
be used as a tocolytic to relax the uterine smooth muscle to delay
- While preferred over
agents such as atosiban and ritodrine, its role has largely been
replaced by the calcium-channel blocker nifedipine, which is more
effective, better tolerated and orally administered.
In 1969, Allen & Hanburys (part of the Glaxo Group, now
GlaxoSmithKline) launched the highly successful asthma drug
Marketed just three years after its synthesis, salbutamol is still
on the market, sold as Ventolin and Proventil.
Salbutamol was one of the earliest drugs developed by rational
design. At the time there were no models of the -receptors
to guide the work; the human -receptor
was not characterized until the 1990s.
- Based on
Preformulation studies different batches of Salbutamol sulphate were
prepared using Xanthan gum, carbopol and ethyl cellulose chosen for
their different hydrophilic properties to calculate the suatained
- Analysis of
Salbutamol is done by UV visible spectrophometer using
- Results of in-vitro
swelling study indicate that the formulation F6 was having
considerable swelling index.
- Visual observation
show that all the coated particles preserve their structural
uncoated salbutamol sulphate particles are unstable at 65% of
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