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  • TFE or trifluoroethyl alcohol, this colourless, water-miscible liquid has a smell reminiscent of ethanol.
  • Due to the electronegativity of the trifluoromethyl group, this alcohol exhibits a stronger acidic character compared to ethanol. Thus, TFE forms stable complexes also with heterocycles (e.g. THF or pyridine) through hydrogen bonding.
  • Trifluoroethanol is produced industrially by hydrogenation or the hydride reduction of derivatives of trifluoroacetic acid, such as the esters or acid chloride.
  • Uses :- A non-aqueous co-solvent that serves as tool to study protein folding. It is also used in various pharmaceutical, chemical and engineering applications.
  • Trifluoroethanol is used as a solvent in organic chemistry. Oxidations of sulfur compounds using hydrogen peroxide are effectively conducted in TFE. Protein denaturant.
  • In biology TFE is used as a co-solvent in protein folding studies with NMR spectroscopy: this solvent can effectively solubilize both peptides and proteins.
  • Industrially trifluoroethanol is employed as a solvent for nylon as well as in applications of the pharmaceutical field.
  • Oxidation of trifluoroethanol yields trifluoroacetaldehyde or trifluoroacetic acid.
  • TFEA As A Solvent :- TFEA is miscible with many oxygen Containing Compounds such As water, alcohols, ethers and ketones.It also dissolves certain Aromatic Compounds such As Benzene and Toluene
  • Energy Fields :- TFEA exhibits Both Extremely Tough Stability as well desirable thermodynamic Properties.TFEA has only found limited use in waste thermal energy recovery systems
  • Anesthetics :- The Synthesis Of medical Anesthetics is the most important known Application For TFEA Certain Ether Derivatives Of TFEA have Been Used As Medical Anesthetics.

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