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Information @ a Glance

General Information

  • Calcium phosphate cements (CPCs) typically harden following the combination of a powder and an aqueous liquid.
  • Calcium phosphate cements are the emerging class of bone substitute materials.
  • The principle of CPCs is the cementing action of acidic and basic calcium phosphate compounds on wetting with an aqueous medium.
  • It has been nearly 30 years since LeGeros and Brown and Chow first developed calcium phosphate cements (CPCs) for biomedical applications.
  • Of these different CPC, the type of precipitation furnishes a classification of the cement type: brushite, hydroxyapatite, calcium-deficient hydroxyapatite, or amorphous calcium phosphate.


  • CPC are made of one or several calcium phosphate (CaP) powders and an aqueous solution. CPCs belong to the category of the low-temperature CaPs that are obtained by precipitation from an aqueous solution at or around room temperature.
  • Calcium phosphate cements (CPCs) were prepared using mixtures of tetracalcium phosphate (TTCP) and dicalcium phosphate anhydrous (DCPA), with TTCP/ DCPA molar ratios of 1/1, 1/2, or 1/3, with the powder and water as the liquid.


  • Calcium phosphate cements control bleeding and are safe to use in osteoporotic sternums during open heart surgery.
  • Calcium phosphate cement (CPC) hardens in situ to form hydroxyapatite and has been used in dental and craniofacial restorative applications.
  • In dentistry calcium phosphate cements play a secondary role at the moment, although they often have excellent bone repair properties.
  • CPC’s have been widely used as a bone tissue engineering scaffold material due to its excellent osteoconductivity, however, in vivo resorption and tissue in growth is slow.


  • Another calcium phosphate cement is also now available on the market in Europe: Calcibon® (Biomet-Merck).
  • Callos is a next generation calcium phosphate cement indicated for filling bony defects in cancellous bone.
  • Approximately there are 300,000 surgeries which use calcium phosphate bone cement for fracture fixation in the U.S annually.
  • The development of calcium phosphate cements (CPC) started almost three decades ago with the formulation of in situ-setting calcium phosphate pastes for dental repair and restoration applications.
  • The most recent calcium phosphate cement to be introduced to the market is a-BSM from Etex Corp.

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