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Information @ a Glance

General

  • Carbosulfan is an anticholinesterase methylcarbamate currently in use as a soil and foliar insecticide.
  • Carbosulfan is a broad-spectrum carbamate pesticide used to control insects, mites and nematodes by soil, foliar and seed treatment applications, mainly on potatoes, sugar beet, rice, maize and citrus.

Toxicity

  • Carbosulfan is minimally irritating to the eye, slightly irritating to the skin and is a dermal sensitizer.
  • In general, in short-term and long-term studies of toxicity, the most sensitive effect of the oral administration of carbosulfan was the inhibition of cholinesterase activity, accompanied at the same or higher doses by clinical signs indicative of cholinesterase inhibition (e.g. salivation, lacrimation, ataxia, tremors, anogenital staining, diarrhoea).
  • The genotoxic potential of carbosulfan was investigated in a wide range of tests. Primarily negative results were obtained in a number of tests in vitro and in vivo. Positive effects were observed in a few tests, however these tests were confounded by the use of very high doses in vivo, the occurrence of marked cytotoxicity in vitro and the lack of information on the purity of the test compound. The Meeting concluded that carbosulfan is unlikely to be genotoxic.
  • Carbosulfan was demonstrated to be moderately toxic acutely when administered to a variety of test animals via various routes of exposure. It did not induce delayed neurotoxicity in atropinized adult Leghorn hens at 500 mg/kg b.w.
     

Uses

  • Carbosulfan is an anticholinesterase methylcarbamate currently in use as a soil and foliar insecticide.
  • Pathological changes were  indicative of ageing mice and many were stated to be masked by use of  short-acting mydriatic solutions.
  • Recent methods used in some of the field trials with citrus fruit and animals are based on the extraction of carbosulfan with dichloromethane (from citrus) or acetone (from animals products) and clean-up on solid-phase extraction (SPE) cartridges before analysis.
  • The concurrent review of carbofuran includes estimates to accommodate residues of carbofuran and 3-hydroxycarbofuran resulting from the use of carbosulfan on citrus fruit.  
  • Since the highest carbamate residues likely to result from the use of carbosulfan in an animal feed item would be about 2 mg/kg from dry citrus pulp with an STMR of 0.29 mg/kg and this is likely to constitute no more than 20-25% of a cattle diet, and since there were no significant residues at the 10 ppm feeding level and relatively low levels even at 50 ppm, the Meeting concluded that no MRL was required for carbosulfan or its metabolites in milk or tissues to accommodate the use of carbosulfan on citrus.
     

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