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Information @ Glance


  • Cholestyramine (CSM) is an FDA-approved medication used to lower elevated levels of cholesterol.
  • Cholestyramine is a quaternary ammonium anion exchange resin with a strong affinity for bile salts.
  • Cholestyramine is a co-polymer of styrene and divinylbenzine, its molecular weight is about one million and it is irisoluble in water.
  • Cholestyramine drug may interfere with the absorption and digestion of fats and fat soluble vitamins such as A, D, E and K. It may be necessary to supplement these vitamins as well as calcium and folic acid.


  • Cholestyramine is also used to treat severe itching caused by liver disease.
  • Cholestyramine can also be used to treat diarrhea.
  • Cholestryamine is also used to treat diarrhea-predominant IBS, cardiac glycoside toxicity, diarrhea associated with excess fecal bile acids (such as in patients with a resected bowel), and pseudomembraneous colitis.
  • Cholestyramine is used to treat the itching that occurs with certain types of liver disease. Itching occurs because of retention of bile salts which are made by the liver. Cholestyramine binds these bile salts in the intestinal tract, thereby reducing them in the blood and relieving the itching that elevated bile salts can cause.


  • Cholestyramine has been used safely for over forty years in millions of patients who have taken the medication for extended periods of time.
  • Cholestyramine can affect how other medications work when taken at the same time. Take other medications 1 hour before or 4 to 6 hours after taking Cholestyramine.
  • Cholestyramine is one of the oldest and relatively safest cholesterol lowering medications on the market today.

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