- Coumachlor is used as a
rodenticide. The chemical may be absorbed through the skin.
Ingestion and other exposures to the chemical can cause various
- Compositions having
rodenticidal activity are disclosed which are constituted by a
solution of a compound having anti-coagulant activity and which is
an indane dione or a 4-hydroxycoumarin, preferably chlorophacinone,
diphacinone, bromadiolone or coumachlor, in a glycol in admixture
with a volatile co-solvent, preferably acetone or dichloromethane,
which increases the solvent activity of the glycol for the
- The enantiomers of the
rodenticide coumachlor were separated by reversed phase HPLC using a
Chirobiotic V column and detected by UV at 254nm.
- Racemic mixtures of five acidic drugs have been successfully
separated by supercritical fluid chromatography (SFC) using
macrocyclic antibiotic chiral stationary phases (CSPs).
- The commercial
ristocetin A CSP (Chirobiotic Rô) was subsequently studied in packed
column SFC with similar results where the enantiomers of
warfarin (Rs = 2.2), coumachlor (Rs = 2.5) and thalidomide (Rs =
0.6) were separated.
- In the case of chiral
separations process, temazepam, aminoglutethimide, benzoin, benzoin
methyl ether, and coumachlor were separated using the three
- The advent of a highly
potent but slow-acting rodenticide molecule, brodifacoum, has
allowed the development of the pulsed baiting technique. This
practical technique is highly effective and offers very significant
savings both in bait and labour compared to first-generation
anticoagulants, with excellent levels of control.
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