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Information @ a Glance

  • Dimercaprol is a chelating (KEE-late-ing) agent. A chelating agent is capable of removing a heavy metal, such as lead or mercury, from the blood.
  • Dimercaprol is used to treat poisoning with arsenic, gold, or mercury. It is also used together with another medication called edetate disodium (EDTA) to treat lead poisoning.
  • Dimercaprol contains not less than 98.5 per cent and not more than the equivalent of 101.5 per cent of (2RS)-2,3 disulfanylpropan-1-ol.
  • Dimercaprol is a clear, colorless or pale yellow liquid. It has a mercaptan-like, disagreeable odor. It is miscible with methanol and with ethanol (99.5). It is soluble in peanut oil, and sparingly soluble in water. It shows no optical rotation.
  • Dimercaprol has a strong odour and gives the breath an unpleasant mercaptan-like odour.
  • Dimercaprol is prepared by the bromination of allyl alcohol to glycerol di-bromine-hydrine followed by reaction with sodium hydrosulfide under pressure. It can also be prepared by  hydrogenizing hydroxide propylene trisulfide .
  • BAL in Oil (Dimercaprol Injection USP) is indicated in the treatment of arsenic, gold and mercury poisoning. It is indicated in acute lead poisoning when used concomitantly with Edetate Calcium Disodium Injection USP.
  • Dimercaprol Injection USP is effective for use in acute poisoning by mercury salts if therapy is begun within one or two hours following ingestion. It is not very effective for chronic mercury poisoning.
  • Dimercaprol as one of the main antidotes used in the management of poisoning by lead and other heavy metals.

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