- Pentetic acid or diethylene triamine
pentaacetic acid (DTPA) is a polyamino carboxylic acid consisting of
a diethylenetriamine backbone with five carboxymethyl groups. The
molecule can be viewed as an expanded version of EDTA and it is used
- DTPA is a calcium (Ca-DTPA) or zinc salt
(Zn-DTPA) that is used to perform medical imaging of the brain,
kidneys, and lungs. It is can also be used to remove certain
radioactive materials, except uranium or neptunium, from a personís
- The conjugate base of DTPA has a high
affinity for metal cations. Thus, the penta-anion DTPA5- is
potentially an octadentate ligand. In contrast, EDTA possesses 6
centres to form coordination bonds with metals. The formation
constants for its complexes are about 100 greater than those for
- DTPA is capable of binding to certain
radioactive materials and speed up the release of these materials in
the urine, thus reducing the amount of internal contamination.
- As a chelating agent, DTPA wraps around a
metal ion by forming up to eight bonds. Transition metals, however,
usually have a limited coordination capacity and can form less than
eight coordination bonds with ligands. So, after forming a complex
with a metal, DTPA still has the ability to bind to other reagents,
as is shown by its derivative pendetide.
- Like the more common EDTA, DTPA is mainly
used for sequestering metal ions that otherwise decompose hydrogen
peroxide, which is used to bleach pulp in paper making. Several
million kilograms are produced for this purpose annually.
- DTPA is only available by injection and is
not available in an oral (by mouth) form. DTPA may be injected directly into a vein
in the arm or dripped into a vein from a bag (intravenously [IV]).
Injection and IV drip are good ways of treating people who might
have been internally contaminated by eating, drinking, or inhaling
radioactive materials or who have contaminated wounds.
- In-CHX-A0-DTPA-labeled hu3S193 diabody and
F(ab9)2 was also evaluated using a BALB/c nude mouse breast
carcinoma xenograft model to ascertain their potential in targeting
expressing solid tumors. CHX-A0-DTPA was added in a molar excess of
3:1 and incubated at room temperature overnight, protected from
- Excess unbound antibody was removed by
dialysis for 8 h with
20 mM sodium acetate buffer containing 0.15 M NaCl (pH 6.4). The pathophysiology and altered alveolar
transfer to Tc-99m-DTPA radioaerosol in the acute and chronic phase
of BLM-injured lungs have been well characterized.
- Chelating agents, such as
diethylenetriamine penta-acetic acid (DTPA), provide an indirect
means of measuring total body storage iron.
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