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Information @ a Glance

  • Ergotamine Tartrate occurs as colorless crystals, or a white to pale yellowish white or grayish white, crystalline powder.

  • Ergotamine is an ergopeptine and part of the ergot family of alkaloids; it is structurally and biochemically closely related to ergoline. It possesses structural similarity to several neurotransmitters, and has biological activity as a vasoconstrictor.

  • The pharmacologic properties of Ergotamine Tartrate are complex; some of the pharmacologic actions are unrelated to each other; some actions are even mutually antagonistic.

  • Ergotamine is a secondary metabolite (natural product) and the principal alkaloid produced by the ergot fungus, Claviceps purpurea, and related fungi in the family Clavicipitaceae.

  • Ergometrine was not easily extractable with solvents due to its tendency to remain in the aqueous phase and, above all, because it was present in scarce quantities in the mixture of alkaloids produced by the Claviceps sclerotia.

  • The ergot fungus Claviceps purpurea produces the medically important ergopeptines, which consist of a cyclol-structured tripeptide and D-lysergic acid linked by an amide bond.

  • Ergot peptide alkaloids, also called ergopeptines, are produced by Claviceps purpurea and consist of cyclol-structured tripeptides attached by amide linkage to D-lysergic acid.

  • Large-scale production of the ergot alkaloids in submerged culture has been confined solely to the commercially important lysergic acid types produced by Claviceps paspali (Arcamone et al. 1961) and C . purpure.

  • Ergotamine Tartrate reduces extracranial blood flow, decreases the amplitude of pulsations in the cranial arteries and decreases hyperperfusion of the basilar artery territory.

  • Ergotamine Tartrate usually only produces small elevations in blood pressure but it does increase peripheral vascular resistance and causes a decrease in blood flow to various organs.

  • Ergotamine is contraindicated in peripheral vascular disease (thromboangiitis obliterans, luetic arteritis, severe arteriosclerosis, thrombophlebitis, Raynaud's disease), coronary heart disease, hypertension, impaired hepatic or renal function, severe pruritus, and sepsis.

  • Ergotamine is an alpha adrenergic blocking agent with a direct stimulating effect on the smooth muscle of peripheral and cranial blood vessels and produces depression of central vasomotor centers.

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