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  • Etoposide is a chemotherapy drug that is usually given to treat lung, ovarian and testicular cancer.
  • Etoposide is a colourless fluid. It is also available as 50mg and 100mg pale pink capsules.
  • Etoposide can cause a rash, which may be itchy.
  • Etoposide is one of the most widely used antineoplastics.
  • Etoposide is often incorrectly referred to as a topoisomerase inhibitor in order to avoid using the term "poison" in a clinical setting.
  • Etoposide forms a ternary complex with DNA and the topoisomerase II enzyme, preventing re-ligation of the DNA strands.
  • Etoposide must not be given by intra-cavity injection.
  • Etoposide is contraindicated in patients with severe hepatic and/or renal dysfunction or in those patients who have demonstrated hypersensitivity to etoposide, podophyllotoxin, podophyllotoxin derivatives or any other component of this preparation.
  • Etoposide is given by an intravenous (IV) infusion (a slow drip through a needle into your port or through a vein in your arm or hand) or infused intraperitoneal (IP; into your abdominal cavity by a special port placed in your abdominal wall), and it is also available in a pill form.
  • Etoposide or etoposide phosphate may be used intravenously as a component of various chemotherapeutic regimens for the treatment of refractory testicular tumours in patients who have already received appropriate surgery, chemotherapy, and radiation therapy.

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