- Hydromorphone, a more
common synonym for dihydromorphinone, commonly a hydrochloride is a
very potent centrally-acting analgesic drug.
- Hydromorphone (Dilaudid®)
belongs to a class of drugs called opioids which includes morphine.
- Hydromorphone may
cause constipation, pupillary constriction, urinary retention,
nausea, vomiting and respiratory depression.
- Hydromorphone is
legally manufactured and distributed in the United States.
- It is considered the
strongest of the antitussive drugs, and was developed shortly after
diacetylmorphine (heroin) was removed from clinical use.
- Hydromorphone is used
to relieve moderate to severe pain and severe, painful dry coughing.
- Hydromorphone was
first synthesized and researched in Germany.
- Hydromorphone is known
in various countries around the world by the trade names Hydal,
Dimorphone, Sophidone LP, Dilaudid, Hydrostat, Hydromorfan,
Hydromorphan, Hymorphan, Laudicon, Hymorphan, Opidol, Palladone, and
hydrochloride (anhydrous) is the salt used in virtually all
hydromorphone products and in prescription compounding at this time.
- Although hydromorphone
is a very good pain killer it is not helpful for all types of pain.
- A GC/MS method
suitable to conduct practical toxicological analyses of unspecified
opiates including hydrocodone or hydromorphone. Silylation can be a
convenient reaction to derivatize unknown analytes in toxicological
analgesia (PCA) is a widely used delivery system for intravenous
(IV) administration of opioids during acute post-operative pain
management. Various opioids have been used for IV PCA including
morphine, meperidine, hydromorphone, and fentanyl.
- The morphine alkaloid
hydromorphone (dihydromorphinone) was identified as an intermediary
metabolite in the degradation of morphine by Pseudomonas putida M10.
- Hydromorphone can be
used as a premedication, alone or in combination with tranquilizers
or sedatives; as part of an induction regime for high-risk patients;
and as an analgesic in the perianesthetic period.
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