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  • Myclobutanil is a conazole class fungicide.
  • It is used heavily to control fungi affecting wine and table grapes, especially in California.
  • Pale yellow solid; does not mix well with water (142 mg/l, 25 C).
  • Soluble in most common solvents such as ketones, esters, alcohols, and aromatic hydrocarbons (all 50-100 g/l).
  • Aqueous solutions decompose on exposure to light DT50 222 d (sterile water), 0.8 d (sensitised sterile water), 25 d (pond water); no hydrolysis (28 C) in 28 d (pH 5,7,9).


  • It also has a number of other food crop and commercial or residential landscaping applications.
  • Myclobutanil is registered for use on a wide range of food and feed crops.
  • It may also be used in greenhouses, public rights of way, turf, and in landscaping applications.
  • Cotton seeds may be treated with myclobutanil (EPA).California accounts for roughly 50% of all myclobutanil use in the US, using 70,000 to 90,000 lbs. annually.
  • Grapes are the most heavily treated crop, using 60% of all myclobutanil in California.
    Almonds and strawberries are also account for a notable percentage of myclobutanil use in California (EPA).


  • In 2005 11.96 million tonnes of apples were produced from 575,796 hectares (ha) in the 25 member states of the European Union .This production was accompanied by high levels of pesticide use.
  • The first registration of a DMI for use against U. necator in Canada was myclobutanil in 1992, 3 years after its registration in the U.S.A. Prior to 1999, myclobutanil gave a high degree of mildew control in commercial vineyards in Ontario and also in experimental programs where it was used exclusively.
  • Myclobutanil and propiconazole were ranked in the 90th percentile for the induction of genes associated with the Nrf2-mediated oxidative stress pathway, based on the normalized distribution of the sum of the gene perturbation values (log10 ratios) across all 1738 reference liver experiments.
  • Leaves with new apple scab lesions were collected in May, June, July and August of 2007, and over 400 isolates of Vi were cultured from these lesions. Fungicide resistance was evaluated in 82 of these isolates by monitoring their growth on agar plates containing 0 ppm, 0.1 ppm, 0.5 ppm, or 1 ppm myclobutanil (Nova 40W).Radial colony growth was measured weekly for 4 weeks. A similar range of fungicide resistance was observed for isolates collected at each sampling interval.
  • Repeated treatments of myclobutanil to a mixed population of Vi may result in a range of fungicide resistance in these populations, but this selective pressure may act over multiple growing seasons.

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