Carboxylic acid derivatives are compounds with functional groups that
can be converted to carboxylic acids by a simple acidic or basic
include esters, amides, nitriles, acid halides, and acid anhydrides.
of -OH and -COOH on same molecule produces a cyclic ester, lactone.
are named as alkyl carboxylates, Alkyl from the alcohol, carboxylate
from the carboxylic acid precursor.
- A recent
synthesis made S-alkyl thiohydroxamic acids readily available, though in
every case only one isomer, inferred to be the anti form, was isolated.
of -NH2 and -COOH on same molecule produces a cyclic amide, lactam.
derivatives of ara-C4 with long linear saturated fattyacids at the A/4
position of ara-C exhibited a higher antitumor activity than did ara-C
in the mouse leukemia L1210 system.
- The ideal
acylating reagent would be a carboxylic acid, but the acids themselves
are relatively unreactive with nucleophiles. A simple solution to this
inactivity, as noted earlier, was to convert the carboxylic acid to a
more reactive derivative such as an acyl chloride or anhydride.
phase HPLC has mainly been applied to pharmaceutical molecules but
Chapter 7 shows how it can be used to separate enantiomers of monacyl
development of acyl derivatives was determined by borohydride reduction
Polybutadiene with a narrow molecular weight is synthesized by anionic
polymerization of butadiene monomer in cyclohexane at 20 ' C using n-butyllithium
as Initiator .
and Nhydroxyacylation, type of organic compound used in each of
N-substitution reactions to ultimately enhance the bioactivity of chitosan.
Acylation is one
of the fundamental reactions in organic chemistry and can be carried out
by wide variety of reagents.
Acyl groups play
an important role in the chemistry of biomolecules.
which is a derivative of corboxylic acid derived from alkyl esters of
alkanoic acids react with carbony1 compounds in an aldol type reaction
forming alkyl @-hydroxyalkanoates.
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