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Information @ a Glance

General

  • 4-Aminophenol is a white powder. It is a breakdown product of paracetamol. The compound is commonly known for its use in the Black and White film developer, Rodinal.

  • p-Aminophenol is a colorless crystalline solid. It is easily oxidizes on air coloring in deep brown tint.

Process

  • 3-Aminophenol has been prepared by treating resorcinol with ammonia under pressure, or fusion of metanilic acid with sodium hydroxide at elevated temperatures.

  • The development of automated colorimetric method for the quantitative determination of p-aminophenol with a Cobas Mira analyzer. An absorbed aniline dose is extensively oxidized to p-aminophenol, which is excreted in urine mainly as glucurono- and sulfo- conjugates.

  • Biotransformation products of hydroxylaminobenzene and aminophenol produced by 3-nitrophenol-grown cells of Pseudomonas putida 2NP8, a strain grown on 2- and 3-nitrophenol, were characterized.

Uses

  • p-Aminophenol is used in production of sulfur and azo dyes.

  • p-Aminophenol and it derivatives of metol, glycine and amidol are photo developers.

  • The intermediate for paracetamol, 4-aminosalicylic acid, sulphur dyes, rubber antioxidant, photo developer.

Report

  • para-Aminophenol is a hair dye precursor. It is incorporated in oxidative hair dye formulations and in the bottle on the market at a maximum concentration of 1.8% and is typically mixed in a 1:1 ratio with an oxidative agent thereby reaching a concentration of 0.9% for in use application.

  • The acetaminophen metabolite, p-aminophenol (PAP), is a known nephrotoxicant. The current study is directed at understanding the mechanism of this nephrotoxicity.

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