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General
  • Aspirin, or acetylsalicylic acid , is a salicylate drug, often used as an analgesic to relieve minor aches and pains, as an antipyretic to reduce fever, and as an anti-inflammatory medication.
  • Aspirin was the first-discovered member of the class of drugs known as non-steroidal anti-inflammatory drugs (NSAIDs).

Process

  • The synthesis of aspirin is classified as an esterification reaction, where the alcohol group from the salicylic acid reacts with an acid derivative (acetic anhydride), yielding aspirin and acetic acid as a byproduct.
  • Formulations containing high concentrations of aspirin often smell like vinegar.
  • This is because aspirin can decompose in moist conditions, yielding salicylic acid and acetic acid.

Report

  • Pharmacy and Pharmaceutical Sciences, found that up to 20 percent of patients taking aspirin to lower the risk of suffering a second cerebro vascular event do not have an antiplatelet response from aspirin, the effect thought to produce the protective effect.
  • That's one of the critical pieces of information was, frequently aspirin resistance occurred in all patients and its prevalence in patients who suffered clinical aspirin failure.

Application

  • Aspirin is one of the most frequently used drugs in the treatment of mild to moderate pain, including that of migraines and fever It is often combined with other non-steroidal anti-inflammatory drugs and opioid analgesics in the treatment of moderate to severe pain.
  • Aspirin has been used to treat pain and arthritis in veterinary medicine, primarily in cats and dogs, although it is often not recommended for this purpose, as there are newer medications available with fewer side effects in these animals.

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