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  • Atenolol is a 1 receptor specific antagonist, a drug belonging to the group of -blockers, a class of drugs used primarily in cardiovascular diseases.
  • Atenolol was developed as a replacement for propranolol in the treatment of hypertension.
  • The chemical works by slowing down the heart and reducing its workload.
  • Atenolol does not pass through the blood-brain barrier thus avoiding various CNS side effects.
  • Atenolol causes significantly fewer central nervous system side effects and fewer bronchospastic reactions, both due to its particular pharmacologic profile.
  • If atenolol alone fails to control arterial hypertension, the drug can be combined with a diuretic or a vasodilator.
  • Atenolol is a member of a class of drugs known as beta-blockers.
  • Atenolol nanoparticles were prepared successfully by DESE technique using EC and PVA.
  • Atenolol acts to inhibit the action of adrenaline on the heart and thereby slows the heart and lowers blood pressure.
  • Therapeutic doses may produce side effects such as dizziness, muscular fatigue, coldness of the fingers and toes, and difficulty in breathing, and/or aggravation of asthma.
  • A HPLC system using RP -C18 column and fluorescence detector was used to assess atenolol in plasma.
  • DESE method involves the dispersion of the aqueous solution of atenolol in a solution of ethylcellulose in dichloromethane.

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