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General
  • Atorvastatin is a member of the drug class known as statins, used for lowering blood cholesterol.
  • This lowers the amount of cholesterol produced which in turn lowers the total amount of LDL cholesterol.

Process

  • It is a completely synthetic compound. HMG-CoA reductase catalyzes the reduction of 3-hydroxy-3-methylglutaryl-coenzyme A to mevalonate, which is the rate-limiting step in hepatic cholesterol biosynthesis.
  • Inhibition of the enzyme decreases de novo cholesterol synthesis, increasing expression of low-density lipoprotein receptors on hepatocytes.

Market

  • A statistically significant negative correlation between market share and mean dose was found for atorvastatin and a positive correlation was found for fluvastatin (P<0.01).
  • Atorvastatin and cerivastatin consistently gained share at the expense of the other four brands over the two year period.

Application

  • Atorvastatin is indicated as an adjunct to diet for the treatment of dyslipidemia, specifically hypercholesterolaemia.
  • It has also been used in the treatment of combined hyperlipidemia.
  • It is used for lowering blood cholesterol.
  • Atorvastatin inhibits the rate-determining enzyme located in hepatic tissue that produces mevalonate, a small molecule used in the synthesis of cholesterol and other mevalonate derivatives.

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