Atorvastatin is a member of the drug class known as statins, used for
lowering blood cholesterol.
- This lowers
the amount of cholesterol produced which in turn lowers the total amount
of LDL cholesterol.
- It is a
completely synthetic compound. HMG-CoA reductase catalyzes the reduction
of 3-hydroxy-3-methylglutaryl-coenzyme A to mevalonate, which is the
rate-limiting step in hepatic cholesterol biosynthesis.
of the enzyme decreases de novo cholesterol synthesis, increasing
expression of low-density lipoprotein receptors on hepatocytes.
statistically significant negative correlation between market share and
mean dose was found for atorvastatin and a positive correlation was found
for fluvastatin (P<0.01).
Atorvastatin and cerivastatin consistently gained share at the expense of
the other four brands over the two year period.
Atorvastatin is indicated as an adjunct to diet for the treatment of
dyslipidemia, specifically hypercholesterolaemia.
- It has also
been used in the treatment of combined hyperlipidemia.
- It is used
for lowering blood cholesterol.
Atorvastatin inhibits the rate-determining enzyme located in hepatic
tissue that produces mevalonate, a small molecule used in the synthesis of
cholesterol and other mevalonate derivatives.
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