Aureofungin - Process , Applications, Patent, Consultants, Uses, Regulatory Act, Suppliers

 Aureofungin
Process , Applications, Patent, Consultants, Uses, Regulatory Act, Suppliers
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  • Aureofungin is a heptaene type of antifungal antibiotic used for controlling plant fungal
    infections and diseases, during pre and post harvesting period of various crops.
  • Polyene antibiotics are known for their remarkable antifungal properties. The alkali metal and quaternary alkylammonium salts of amphotericin B, nystatin and aureofungin have been prepared by ion-exchange method.
  • The physico-chemical and biological properties of these salts have been studied with a view to evaluate their therapeutic advantages over the parent
    compounds.
  • Biosynthesis of aureofungin by Streptoverticillium cinnamoneum var, terricola was found to be an oxygen dependent reaction. An accelerated rate of aureofungin production, along with a better yield coefficient were obtained under conditions of enhanced aeration during fermentation. A higher oxygen transfer rate was found to stimulate aureofungin A, and suppresses aureofungin B formation.
  • The widely used agricultural antifungal agent aureofungin (ARF) was subjected to genotoxicity assessment using the Ames Salmonella assay as well as the in vivo micronucleus test and dominant lethal test in Swiss mice.
  • The root of coconut gardens in Arsikere feeding with Aureofungin-sol (1.3%) + Bordeaux mixture (1(Yo) soil drenching at quarterly interval along with soil application of neem cake at 5 kg/palm/year was found to be most effective in checking the disease.

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