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Information @ a Glance

  • Bioperine® is a standardized extract from the fruit of Piper nigrum L (black pepper) or Piper longum L (long pepper). It contains 95 percent of piperine. Bioperine® may be co-administered with various nutrients for both human and animal health. Bioperine® extract obtained from the black pepper fruit that is cultivated in the damp, nutrient-rich soil regions of southern India .
  •  The delicate pepper berries are harvested just prior to ripening and then sun dried to assure optimum maturity and quality. The extract of piperine, called Bioperine® in the patented form, has been clinically tested in the United States . Bioperine® significantly enhances the bioavailability of various supplement nutrients through increased absorption.

Extraction Process

  • A bioassay-guided isolation of the ethanol extract from the fruits of Piper longum yielded a known piperidine alkaloid, piperine, as a monoamine oxidase (MAO) inhibitor. Piperine showed an inhibitory effect. Some results suggest that piperine possesses potent antidepressant-like properties that are mediated in part through the inhibition of MAO activity, and therefore represent a promising pharmacotherapeutic candidate as an antidepressant agent.
  • It is interesting to note that the proportions of piperin can vary the simple one with the double according to pepper and that while following the same protocol of extraction. Piperin is presented in the form of pale crystals yellow, with iridescent reflections, melting between 127 and 130°C. The crystals are prismatic, to four sides, and belong to the monoclinical system.


  • The advantage of utilizing black pepper (as opposed to the standard quinine) in the treatment of refractory intermittent fevers, which are symptomatic of malarial infections. It was reported that long pepper was used for patients with chronic malaria with splenomegaly (enlarged spleen). The use of black pepper, long pepper, or trikatu is traditionally well-known in the treatment of a variety of gastrointestinal disorders, and all three act to improve digestion.
  • Best Curcumin w/Bioperine contains a standardized extract of Curcuma longa root, commonly known as “Turmeric.” Turmeric is a yellow spice used in curried dishes. In the Far East, turmeric is valued for more than just its culinary applications. Bioperine is added as a natural bioenhancer to promote absorption of the product.

Market & Report

  • World Pepper production, as per International Pepper Community (IPC) projection, of around 300,000 metric tons during 2003 is dominated by Asia region accounting for 65-70% of total production. The region caters for three-quarters of the total export market. This facts clearly portray the importance that the Asian region has in the world pepper trade.
  • In India, pepper vines usually flower during May to June with the commencement of the monsoon. It takes about six to eight months from flowering to harvest. The main harvesting season is from November- December in the plains and January to March in the hills. India dominates world pepper market given its consumption and production pattern.
  • When volunteers took Bioperine® (a proprieary black pepper extract) along with certain nutrients, blood levels of the nutrients were significantly higher in the extract group than in the blood levels of the placebo group. Piperine, is a patent-pending form of "Bioperine" which has been proved in medical trials and research to enhance the body’s natural thermogenic activities.

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