Bronopol                                                                                                         Process, Standards, Applications, Patent, Product, Company Profiles, Reports, MSDS                                                                     Primary Information Services                                                          Home. Ordering Information. Contact  

Information @ a Glance

General

  • Bronopol (INN) is a highly active antimicrobial chemical compound whose chemical formula is 2-bromo-2-nitropropane-1,3-diol.
  • Bronopol was invented by The Boots Company PLC, Nottingham, England.
  • Bronopol is supplied as crystals or crystalline powder.
  • Bronopol is readily soluble in water although the dissolution process is endothermic.
  • Bronopol is also a formaldehyde releaser.
  • Bronopol is easily biodegradable.

Process

  • Bronopol is effective in pH 5-8 and presumably more so in alkaline environments where it is also more rapidly degraded.
  • A contaminant is formed in the synthesis of Bronopol and is a known formaldehyde former.
  • Bronopol, 2-bromo-2-nitroethanol and bromonitromethane were measured using HPLC and electrochemical detectors.
  • Bronopol undergoes rapid hydrolysis as well as biodegradation, which may explain its absence in the environmental matrix samples.
  • A screening process were made on biocides for seawater thin film membrane compatibility and biocidal efficacy. The screening studies resulted in three promising biocides: Minnacare, Bronopol, and sodium bisulfite.

Application

  • Bronopol was subsequently taken up as an effective antimicrobial in many industrial environments such as paper mills, oil exploration and production facilities, as well as cooling water disinfection plants.
  • Bronopol is used in consumer products as an effective preservative agent, as well as a wide variety of industrial applications.
  • Bronopol is readily soluble in water although the dissolution process is endothermic.
  • 2-Bromo-2-nitropropane-1,3-diol (bronopol) has a broad spectrum of antibacterial activity (12) and is widely used, at concentrations of up to 0.1% (wt/vol), as a preservative for pharmaceutical and cosmetic products.

Report

  • Biocides introduced to the market after May 2000 have to be identified to the EC prior to authorisation.
  • A research analyst suggested that there is a strong potential for growth of the biocides market in the plastics industry.
  • Bronopol is officially classified in the EU Council Directive - 67/548/EEC as harmful, irritant and dangerous for the environment.
  • Using bronopol microtabs versus potassium dichromate will cost the laboratory approximately $160 per month more since bronopol is more expensive than potassium dichromate.

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