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Information @ a Glance

General

  • Calcitonin is a 32 amino acid polypeptide hormone that is produced in humans primarily by the Parafollicular cells of the thyroid, and in many other animals in the ultimobranchial body.

  • Calcitonin is a hormone known to participate in calcium and phosphorus metabolism. In mammals, the major source of calcitonin is from the parafollicular or C cells in the thyroid gland, but it is also synthesized in a wide variety of other tissues, including the lung and intestinal tract. In birds, fish and amphibians, calcitonin is secreted from the ultimobrachial glands.

  • Calcitonin is an endogenous hormone that has been identified in different forms in more than 15 species of mammals, birds, amphibians and fish, and even in unicellular organisms.

Technology

  • To assess the functional role of calcitonin during implantation, we recently employed an antisense technology to regulate calcitonin gene expression in rat uterus.

  • Calcitonin gene related peptide (CGRP) related molecules were purified from sardine hydrolysates prepared using 0.1% alcalase and two hours of hydrolysis. Gel exclusion chromatography and HPLC performed purification of these molecules.

Application

  • Calcitonin is considered the drug of choice for the management of acute pain associated with vertebral fracture secondary to osteoporosis.

  • Calcitonin is a man-made hormone that works by slowing bone loss and maintaining normal calcium levels in the blood. It may also help to reduce bone pain in people who have Paget's disease.

  • Salmon calcitonin nasal spray at a dose of 200 IU dady significantly reduces the risk of new vertebral fractures in postmenopausal women with osteoporosis.

Market

  • A joint venture between US-based Unigene Laboratories and China's Shijiazhuang Pharmaceutical Group will begin selling injectable calcitonin in China for the treatment of osteoporosis.

  • The osteoporosis pharmaceutical market is currently $7 billion and is expected to grow to $14 billion by 2011. According to IMS, a market research firm, worldwide sales of an existing Calcitonin-Salmon Nasal Spray were approximately $389 million in current year, of which the U.S. accounts for an estimated $240 million. 

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