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  • Chlorhexidine is a chemical antiseptic. It kills both gram-positive and gram-negative microbes, although it is less effective with some gram-negative microbes.
  •  It is also bacteriostatic.


  • The mechanism of action is believed to be membrane disruption, and not ATPase inactivation as previously thought.
  • Chlorhexidine is deactivated by anionic compounds, including the anionic surfactants .
  • It has been shown to have an immediate bactericidal action and a prolonged bacteriostatic action due to adsorption onto the pellicle coated enamel surface.


  • It is sometimes marketed under the brand names Peridex, Periochip or Periogard Oral Rinse.
  • In the UK it is mainly marketed under the brand name Corsodyl; in Germany as Chlorhexamed; in Australia as Savacol; in India as Clohex or Dejavu-MW.


  • It is often used as an active ingredient in mouthwash designed to kill dental plaque and other oral bacteria Chlorhexidine can thus be used to improve bad breath.
  • It is commonly used as detergents in toothpastes and mouthwashes.
  • It is often used as a rubbing agent prior to the use of hypodermic or intravenous needles in place of iodine.

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