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Information @ a Glance


  • Eugenol (C10H12O2), is an allyl chain-substituted guaiacol.

  • Eugenol is a member of the phenylpropanoids class of chemical compounds.

  • It is a clear to pale yellow oily liquid extracted from certain essential oils especially from clove oil, nutmeg, cinnamon, and bay leaf.

  • It is slightly soluble in water and soluble in organic solvents. It has a pleasant, spicy, clove-like aroma.

  • Eugenol is sometimes called clove oil because it is the active element in cloves.

  • Besides cloves, it can also be extracted from cinnamon and other aromatic spices.


  • Essential oils are volatile, ethereal liquids of oily consistency. They are extracted from plants, usually by steam distillation or extraction.

  • Eugenol is the main ingredient of the essential oil that can be isolated from the spice clove.

  • Eugenol contains a carbon-carbon double bond and an aromatic hydroxyl group called a phenol. These functional groups provide the basis for simple chemical tests used to characterize the clove oil.


  • Eugenol is used in perfumeries, flavorings, essential oils and in medicine as a local antiseptic and anesthetic.

  • It is a key ingredient in Indonesian kretek (clove) cigarettes.

  • Eugenol derivatives or methoxyphenol derivatives in wider classification are used in perfumery and flavoring.

  • They are used in formulating insect attractants and UV absorbers, analgesics, biocides and antiseptics. They are also used in manufacturing stabilizers and antioxidants for plastics and rubbers.

  • Eugenol is a phenol derivative that is used in combination with zinc oxide as a surgical dressing, pulp capping agent, cavity liner, temporary cement, and in mouthwashes and endodontic therapy.

  • Eugenol is found as a major ingredient in a variety of dental materials such as impression materials, filling materials, dental cements, endodontic sealers, periodontal dressing materials and dry socket dressings.


  • Eugenol was the compound responsible for antifungal activity of the essential oil of O. gratissimum.

  • The capacity of a zinc oxide-and eugenol-based root canal sealer in penetrating into lateral canals depends on two factors: the physical properties of the material and the correct manipulation of the sealer, respecting the powder-liquid ratio and observing the ideal clinical consistency for obturation, which is more important and, also, more controllable by the dentist.

  • Eugenol is widely used in dentistry. It is generally used without incident however in a sensitised individual it can cause a range of tissue effects, from low-grade local reactions to the rare, but serious, anaphylactic reaction.

  • Eugenol is not a bio-friendly material and patients should be discouraged from using it in its pure form, either to alleviate toothache or dentine hypersensitivity.

  • Eugenol containing materials need to be used in the appropriate amounts and manufacturer's instructions should be followed. For patients who are allergic to eugenol, eugenol-free alternatives are available.

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