- Furosemide (INN) or
frusemide (former BAN) is a loop diuretic.
- It is most commonly
marketed by Sanofi-Aventis under the brand name Lasix.
- The name of lasix is
derived from lasts six (hours) -- referring to its duration of action.
- Furosemide is a
noncompetitive subtype-specific blocker of GABA-A receptors.
- Furosemide is
odorless white to slightly yellow crystalline powder.
- Furosemide is a
diuretic which is an anthranilic acid derivative.
- Furosemide may
undergo hydrolysis at sufficiently low pH.
- The spherical
agglomeration process is used to delay the dissolution of furosemide.
- Hyperprostaglandin E
syndrome/antenatal Bartter syndrome (HPS/aBS), a salt-losing tubulopathy
of the furosemide type , is clinically characterized by polyhydramnios
leading to premature delivery, hypoisosthenuria with marked polyuria,
and severe hypercalciuria resulting in nephrocalcinosis.
metabolism of frusemide is carried out by the intestine while systemic
clearance of frusemide is mainly performed by the kidneys with
contributions from the intestine and the liver.
- Frusemide is commonly
used in conditions such as heart failure, where the pumping mechanism of
the heart is less effective.
- Frusemide is also
used to remove excess fluid associated with liver failure, hypertension,
and poor circulation in the periphery (ie arms and legs).
- Frusemide is
frequently used to facilitate fluid and electrolyte management of acute
renal failure in many institutions.
- Furosemide increases
water content in renal tissue.
elimination of 18F-FDG can be mistaken for pathologic uptake. Furosemide
helps eliminate this artifact.
- The short-term
effects of intravenous administration of furosemide on key functions in
the kidney cortex and the outer and inner medulla of rats has been
evaluated using magnetic resonance imaging (MRI) technique.
Microspheres were prepared by the ionic cross linking technique using
cacl2, Al2(so4)3 and bacl2.
- NIR spectroscopy
technique was used to evaluate 48 different formulations of furosemide
urography technique is used in hypertensive patients who would be having
angiography and renal vein renin determinations to establish the
presence or absence of renovascular hypertension.
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