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Information @ a Glance

General

  • Furosemide (INN) or frusemide (former BAN) is a loop diuretic.
  • It is most commonly marketed by Sanofi-Aventis under the brand name Lasix.
  • The name of lasix is derived from lasts six (hours) -- referring to its duration of action.
  • Furosemide is a noncompetitive subtype-specific blocker of GABA-A receptors.
  • Furosemide is odorless white to slightly yellow crystalline powder.
  • Furosemide is a diuretic which is an anthranilic acid derivative.

Process

  • Furosemide may undergo hydrolysis at sufficiently low pH.
  • The spherical agglomeration process is used to delay the dissolution of furosemide.
  • Hyperprostaglandin E syndrome/antenatal Bartter syndrome (HPS/aBS), a salt-losing tubulopathy of the furosemide type , is clinically characterized by polyhydramnios leading to premature delivery, hypoisosthenuria with marked polyuria, and severe hypercalciuria resulting in nephrocalcinosis.
  • Pre-systemic metabolism of frusemide is carried out by the intestine while systemic clearance of frusemide is mainly performed by the kidneys with contributions from the intestine and the liver.

Application

  • Frusemide is commonly used in conditions such as heart failure, where the pumping mechanism of the heart is less effective.
  • Frusemide is also used to remove excess fluid associated with liver failure, hypertension, and poor circulation in the periphery (ie arms and legs).
  • Frusemide is frequently used to facilitate fluid and electrolyte management of acute renal failure in many institutions.
  • Furosemide increases water content in renal tissue.
  • Urinary-system elimination of 18F-FDG can be mistaken for pathologic uptake. Furosemide helps eliminate this artifact.

Technology

  • The short-term effects of intravenous administration of furosemide on key functions in the kidney cortex and the outer and inner medulla of rats has been evaluated using magnetic resonance imaging (MRI) technique.
  • Furosemide-Loaded Microspheres were prepared by the ionic cross linking technique using cacl2, Al2(so4)3 and bacl2.
  • NIR spectroscopy technique was used to evaluate 48 different formulations of furosemide tablets.
  • Furosemide-augmented urography technique is used in hypertensive patients who would be having angiography and renal vein renin determinations to establish the presence or absence of renovascular hypertension.

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