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  • Glibenclamide, also known as glyburide, is an anti-diabetic drug in a class of medications known as sulfonylureas, used in the treatment of type II diabetes.
  • Glyburide is in a class of drugs called sulfonylureas.
  • It is used to help control blood sugar levels.
  • Treatment with glyburide may increase the risk of death from cardiovascular disease compared to treatment of diabetes with diet alone or diet plus insulin.


  • The drug works by inhibiting ATP-sensitive potassium channels in pancreatic beta cells.
  • This inhibition causes cell membrane depolarization, opening of voltage-dependent calcium channels, thus triggering an increase in intracellular calcium into the beta cell which stimulates insulin release.


  • The whole-cell patch-clamp technique was used in adult mouse ventricular myocytes at 22C to study the transient outward current and its sensitivity to the antimycotics miconazole and clotrimazole, as well as to glybenclamide.
  • Inhibition of ATP-sensitive K+ channels and the resultant depolarization are essentially involved in the mechanisms by which antidiabetic sulfonylureas drugs , repaglinide, and nateglinide1. stimulate insulin secretion from pancreatic b-cells.


  • To identify among women with gestational diabetes mellitus the patient characteristics that predict treatment failure with glyburide.
  • Glyburide was more likely to fail in women diagnosed earlier in pregnancy, of older age and multi parity, and with higher fasting glucoses, suggesting that earlier glucose intolerance and a reduced capacity to respond to an insulin secretagogue may distinguish this group.

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