Glibenclamide, also known as glyburide, is an anti-diabetic drug in a
class of medications known as sulfonylureas, used in the treatment of type
is in a class of drugs called sulfonylureas.
- It is used
to help control blood sugar levels.
with glyburide may increase the risk of death from cardiovascular disease
compared to treatment of diabetes with diet alone or diet plus insulin.
- The drug
works by inhibiting ATP-sensitive potassium channels in pancreatic beta
inhibition causes cell membrane depolarization, opening of
voltage-dependent calcium channels, thus triggering an increase in
intracellular calcium into the beta cell which stimulates insulin release.
whole-cell patch-clamp technique was used in adult mouse ventricular
myocytes at 22°C to study the transient outward current and its
sensitivity to the antimycotics miconazole and clotrimazole, as well as to
of ATP-sensitive K+ channels and the resultant depolarization are
essentially involved in the mechanisms by which antidiabetic sulfonylureas
drugs , repaglinide, and nateglinide1. stimulate insulin secretion from
- To identify
among women with gestational diabetes mellitus the patient characteristics
that predict treatment failure with glyburide.
was more likely to fail in women diagnosed earlier in pregnancy, of older
age and multi parity, and with higher fasting glucoses, suggesting that
earlier glucose intolerance and a reduced capacity to respond to an
insulin secretagogue may distinguish this group.
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