Insulin is a hormone with intensive effects on both
metabolism and several other body systems .
secreted by groups of cells within the pancreas called islet
Insulin delivery systems include: Insulin pens, insulin jet
injectors, external insulin pumps, implantable pumps, insulin
patches, insulin inhalers, oral insulins and islet cell
Insulin is a
peptide drug, hence is still a challenging and uncompromised
drug molecule that cannot be given in oral dosage form.
The advanced methods of insulin delivery system would
gradually progress towards physiological insulin replacement and
reduce the long-term complications of diabetes mellitus.
basal delivery of
insulin has been a major goal for
the treatment of diabetes mellitus (DM), which affects more than
21 million individuals in the United States.
developments have occurred in the delivery system of insulin
during the last twenty years and each improvement was aimed at
two common goals: patients convenience and better glycemic
Novo Nordisk, who
dominates the world insulin market, now also has a stranglehold
on the world insulin delivery device market, holding a 70 per
cent share with its range of pen devices.
In future, more
acceptable and cost effective insulin inhaler will be
introduced. Newer avenues are under extensive trial for better
future insulin delivery systems.
of non-invasive insulin delivery methods is set to overcome
their high cost and concerns about safety and efficacy, with the
greatest beneficiary being the European inhaled insulin market
which is predicted to swell from $49.3m (€38.5m) in 2006 to
$611.7m in 2012
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