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Information @ a Glance


  • L-DOPA (3,4-dihydroxy-L-phenylalanine) is an intermediate in dopamine biosynthesis.
  • In clinical use, Levodopa (INN) is administered in the management of Parkinson's disease.
  • L-Dopa is also used as a component in marine adhesives used by pelagic life.
  • Once levodopa has entered the central nervous system (CNS), it is metabolized to dopamine by aromatic L-amino acid decarboxylase.


  • L-DOPA is produced from the amino acid tyrosine by the enzyme tyrosine hydroxylase.
    Dopamine is formed by the decarboxylation of L-DOPA.
  • L-DOPA can be directly metabolized by catechol-O-methyl transferase (COMT) to 3-O-methyldopa (3-OMD) and then further to vanillactic acid.
  • Both levodopa and its precursor amino acid L-tyrosine are precursors to the biological pigment melanin.
  • The enzyme tyrosinase catalyzes the oxidation of L-dopa to the reactive intermediate dopaquinone, which reacts further, eventually leading to melanin oligomers.


  • Effects of Anonaine on Dopamine Biosynthesis and L-DOPA-Induced Cytotoxicity in PC12 Cells.
  • Functions of Deep Brain Stimulation and L-dopa in Walking Features of Parkinsonian Patients.
  • Effect of L-dopa on Nocturnal Prolactin Surges During Pseudopregnancy.
  • Neurotrophic Effects of L-DOPA in Postnatal Midbrain Dopamine Neuron/Cortical Astrocyte Cocultures


  • L-Dopa Feeding Induces Body Growth and Reproductive Conditions in Japanese Quail, Coturnix coturnix Japonica.
  • The influence of intermittent l-Dopa trearment on striatal molecular markers in hempiparkinsonian rats.
  • Production of 1-3:4, dihydroxyphenylalanine from tyrosine from various sources detailed study.
  • Assessment details of pharmacokinetic interaction of L-Dopa and benserazide.

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