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  • Lamivudine  is a potent nucleoside analog reverse transcriptase inhibitor.
  • Lamivudine is administered orally, and it is rapidly absorbed with a bio-availability of over 80%. Some research suggests that lamivudine can cross the blood-brain barrier.


  • Lamivudine is an analogue of cytidine.
  • It can inhibit both types of HIV reverse transcriptase and also the reverse transcriptase of hepatitis B.
  • It needs to be phosphorylated to its triphosphate form before it is active.
  • 3TC-triphosphate also inhibits cellular DNA polymerase.


  • Lamivudine is a nucleoside analogue, which was originally licensed for the treatment of HIV.
  • It is now additionally licensed for the treatment of chronic hepatitis B with evidence of viral replication.
  • It is marketed by GlaxoSmithKline with the brand names Zeffix, Heptovir, Epivir, and Epivir-HBV.


  • Lamivudine has been used for treatment of chronic hepatitis B at a lower dose than for treatment of HIV.
  • It improves the sero conversion of e-antigen positive hepatitis B and also improves histology staging of the liver.

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