is a potent nucleoside analog reverse transcriptase inhibitor.
is administered orally, and it is rapidly absorbed with a bio-availability
of over 80%. Some research suggests that lamivudine can cross the
is an analogue of cytidine.
- It can
inhibit both types of HIV reverse transcriptase and also the reverse
transcriptase of hepatitis B.
- It needs to
be phosphorylated to its triphosphate form before it is active.
3TC-triphosphate also inhibits cellular DNA polymerase.
is a nucleoside analogue, which was originally licensed for the treatment
- It is now
additionally licensed for the treatment of chronic hepatitis B with
evidence of viral replication.
- It is
marketed by GlaxoSmithKline with the brand names Zeffix, Heptovir, Epivir,
has been used for treatment of chronic hepatitis B at a lower dose than
for treatment of HIV.
- It improves
the sero conversion of e-antigen positive hepatitis B and also improves
histology staging of the liver.
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