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Information @ a Glance

General
  • Lysergol, is an alkaloid of the ergoline family that occurs in various species of vines of the Convolvulaceae and some species of fungi. As the minor alkaloid in the hallucinogenic seeds of Rivea corymbosa (ololiuhqui), Argyreia nervosa (Hawaiian baby woodrose) and Ipomoea violacea.
  • Lysergol is uncontrolled in the USA, but possession and sale may be illegal under the Federal Analog Act because of its relationship to LSD and ergine, which are controlled substances.

Process

  • A series of simple O-acylated derivatives of the naturally occurring clavine alkaloids lysergol and dihydrolysergol-I were synthesized and tested in-vitro for their ability to interact with 5-HT2A receptors in rat tail artery, 5-HT2C receptors in piglet choroid plexus, 5-HT1B receptors in guinea-pig iliac artery and alpha1-adrenergic receptors in rat aorta.
  • lysergol and its N(1)-unsubstituted derivatives were found to be partial agonists (alpha of 0.2-0.4) for 5-HT2C receptor-mediated inositol phosphate accumulation in piglet choroid plexus.
  • It is concluded that O-acylated derivatives of the clavine alkaloids lysergol and dihydrolysergol-I mimic therapeutically relevant ergolines due to the complexity of their pharmacological profile as partial agonists and antagonists at 5-HT2A, 5-HT2C and 5-HT1B receptors, and at alpha1-adrenergic receptors.

Report

  • In terms of market cost, lysergol is much cheaper than ergonovine and lysergic acid derivatives while ergonovine is the most costly among all the alkaloids assayed, thereby indicating the economic importance of these advantageous changes in the spectra of alkaloids with the use of the SSF(Solid State Fermentation) system.
  • In the examination of relative and potential transport of ergoline and ergopeptine alkaloids across isolated gastric tissues in vitro, Ergot alkaloids used were a mixture of lysergol, lysergic acid, ergonovine, ergocryptine, and ergotamine tartrate. Lysergol, lysergic acid, and ergonovine were selected because they represent the alcohol, acid, and amide forms of the ergoline alkaloids, respectively.
  • A strategy has been suggested to prevent the fescue toxicosis by preventing the absorption of the alkaloids rather than trying to block their etabolic effect once they are in the circulatory system. Lysergic acid, lysergol, and ergonovine have exhibited the greatest absorption potential compared to the ergopeptine alkaloids that have been the main toxins implicated in fescue toxicosis.

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