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Information @ a Glance

General

  • Mebendazole or MBZ, marketed as Ovex, Vermox, Antiox or Pripsen, is a benzimidazole drug that is used to treat infestations by worms including pinworms, roundworms, tapeworms, hookworms, and whipworms.

  • It works by interfering with proteins in either the worm's intestine or absorptive cells. This leads to the worm not being able to absorb sugars which are essential for its survival.

  • The active ingredient in Pripsen powder is piperazine.

  • Mebendazole is a white to slightly yellow powder with a molecular weight of 295.29.

  • It is less than 0.05% soluble in water, dilute mineral acid solutions, alcohol, ether and chloroform, but is soluble in formic acid.

Process

  • Treatment of lung cancer cell lines with MZ caused mitotic arrest, followed by apoptotic cell death with the feature of caspase activation and cytochrome c release. MZ induces abnormal spindle formation in mitotic cancer cells and enhances the depolymerization of tubulin.

  • MZ (methyl 5-benzoyl-2-benzimidazole-carbamate) is a broad-spectrum anthelmintic drug that has been used to treat helminthic diseases in humans all over the world.

  • Mebendazole treatment had a downregulatory effect on the serum levels of specific anti-Toxocara IgE antibodies, while those of total IgE antibodies were not affected either with the use of diethylcarbamazine or by mebendazole.

  • Resistance has been widely reported in livestock parasites after frequent de-worming, and although benzimidazole resistance has so far not been conclusively demonstrated in human hookworms, drug resistance may explain the apparent decline in mebendazole efficacy seen after repeated mass treatment with mebendazole.

  • Treatment of trichuriasis with mebendazole 500 mg yielded cure rates of 93.9 and 88.9% respectively.

  • In recent years, chemotherapy with mebendazole (MBZ), the benzimidazole-carbamate compound that has been extensively used in the treatment of helmintic infections, has also demonstrated in vitro activity against Giardia duodenalis (G. duodenalis).

Techniques

  • Recently, antihelmintic drugs, benzoimidazole carbamate derivatives (albendazole and mebendazole) have been tried in hydatid disease, with and without surgery.

  • Even though the mechanism of action is not known exactly, it probably prevents the glucose uptake of the parasite and therefore production of ATP.

  • When compared with albendazole, mebendazole has a decreased uptake in the intestines, which means that mebendazole treatment is required for longer with higher doses.

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