Metformin-Hydrochloride                             

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Information @ a Glance

General

  • Metformin Hydrochloride is an anti-diabetic preparation.

  • Metformin hydrochloride is a white, crystalline powder which is odourless or almost odourless and hygroscopic.

  • It is freely soluble in water, slightly soluble in ethanol (96%), and practically insoluble in chloroform and ether.

  • The chemical name for metformin hydrochloride is 1,1-dimethylbiguanide hydrochloride.

  • Metformin is an oral biguanide hypoglycaemic agent.

Process

  • Metformin is excreted unchanged in the urine and does not undergo hepatic metabolism.

  • A simple and rapid HPLC assay method for the estimation of metformin in human plasma was developed and validated.

  • Extended release (ER) formulation of metformin hydrochloride (HCl) investigates the possibility for development of a direct compression ER matrix tablet using hypromellose.

  • The synthesis, characterization and pharmacodynamic evaluation of the copper [Cu2+] and nickel [Ni2+] complexes of metformin have been studied.

Uses

  • Metformin may be used as initial treatment or in sulfonylurea failures either alone or in combination with a sulfonylurea and other oral agents.

  • Metformin hydrochloride is an oral biguanidine, which reduces the elevated blood glucose concentration in patients with diabetes but does not increase insulin secretion.

  • Metformin hydrochloride is a high-dose drug widely used as an oral anti-hyperglycemic agent.

Technology

  • Small size and improved release technology has evolved the therapy of metformin. Thus, metformin still is used as a therapeutic agent of first choice for monotherapy of the typical overweight patient.

  • A simple, rapid and precise method is developed for the quantitative simultaneous determination of metformin hydrochloride and rosiglitazone maleate in a combined pharmaceutical-dosage form.

  • A high performance reverse phase liquid chromatographic procedure is developed for the Simultaneous estimation of Metformin Hydrochloride and Pioglitazone hydrochloride in combined tablet dosage form.

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