- Methionine is a
neutral, genetically coded aminoacid. It is essential in human
- met m
- Molecular weight
- 2.28, 9.21
- CAS Registry
involved in methionine biosynthesis are aspartokinase β-aspartate
semialdehyde dehydrogenase homoserine dehydrogenase homoserine
acyltransferase cystathionine-γ-synthase cystathionine-β-lyase
- Racemic methionine
can be synthesized from diethyl sodium phthalimidomalonate,
(C6H4(CO)2NC(CO2Et)2), by alkylation with chloroethylmethylsulfide,
ClCH2CH2SCH3 followed by hydrolysis and decarboxylation.
- High levels
of methionine can be found in sesame seeds, Brazil nuts, fish, meat, and
some seeds. Most fruit and vegetables contain very little; however, some
have significant amounts, such as spinach, potatoes, and boiled corn.
- Methionine is used
as dietary component in the poultry and animal feed.
is essential nutrient and lipotropic agent. It is used widely in feed
is essential component in human nutrition, as it is not synthesized by
the human body and is used as feedstuff for broilers.
plays an important role in biological methylations.
- The fine
chemicals industry is turning increasingly to biological synthesis
routes to fulfill the rapidly growing demand for enantiomerically pure
- The rapidly
changing product demands that are typical for chiral intermediates,
however, can limit the ability of biocatalysis to compete with other
global demand for methionine is around 450,000 - 500,000 tons per year.
However, this demand is expected to grow more than 5 percent annually,
particularly in Asia, as poultry consumption increases alongside growing
populations and rising standards of living in industrializing nations.
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