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Information @ a Glance

 General
  • Methionine is a neutral, genetically coded aminoacid. It is essential in human nutrition.
    Symbol
    met m
    Molecular formula
    C5H11NO2S
    Molecular weight
    149.21
    Isoelectric point (pH)
    5.74
    pKa values
    2.28, 9.21
    CAS Registry Number
    63-68-3

Process

  • Enzymes involved in methionine biosynthesis are aspartokinase β-aspartate semialdehyde dehydrogenase homoserine dehydrogenase homoserine acyltransferase cystathionine-γ-synthase cystathionine-β-lyase methionine synthase
  • Racemic methionine can be synthesized from diethyl sodium phthalimidomalonate, (C6H4(CO)2NC(CO2Et)2), by alkylation with chloroethylmethylsulfide, ClCH2CH2SCH3 followed by hydrolysis and decarboxylation.
  • High levels of methionine can be found in sesame seeds, Brazil nuts, fish, meat, and some seeds. Most fruit and vegetables contain very little; however, some have significant amounts, such as spinach, potatoes, and boiled corn.

Application

  • Methionine is used as dietary component in the poultry and animal feed.
  • Methioninet is essential nutrient and lipotropic agent. It is used widely in feed mixes.
  • Methionine  is essential component in human nutrition, as it is not synthesized by the human body and is used as feedstuff for broilers.
  • Methionine plays an important role in biological methylations.

Market

  • The fine chemicals industry is turning increasingly to biological synthesis routes to fulfill the rapidly growing demand for enantiomerically pure pharmaceuticals.
  •  The rapidly changing product demands that are typical for chiral intermediates, however, can limit the ability of biocatalysis to compete with other technologies.
  • Current global demand for methionine is around 450,000 - 500,000 tons per year. However, this demand is expected to grow more than 5 percent annually, particularly in Asia, as poultry consumption increases alongside growing populations and rising standards of living in industrializing nations.

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