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General
  • Metronidazole is an antibiotic used to treat different kinds of infections.
  • Metronidazole is a nitroimidazole anti-infective medication used mainly in the treatment of infections caused by susceptible organisms, particularly anaerobic bacteria and protozoa.

Process

  • Metronidazole is a prodrug,It is converted in anaerobic organisms by the redox enzyme pyruvate-ferredoxin oxidoreductase.
  • The nitro group of metronidazole is chemically reduced by ferredoxin  and the products are responsible for disrupting the DNA helical structure, thus inhibiting nucleic acid synthesis.

Market

  • Metronidazole marketed by Pfizer under the trade name Flagyl in the US, while Sanofi-Aventis markets metronidazole globally under the same trade name,  Flagyl, and also by various generic manufacturers, who sell it at a lower price.
     

Application

  • Metronidazole has also been used in women to prevent preterm birth associated with bacterial vaginosis, amongst other risk factors including the presence of cervicovaginal fetal fibronectin.
  • A randomised controlled trial demonstrated that metronidazole was ineffective in preventing preterm delivery in high-risk pregnant women and, conversely, the incidence of preterm delivery was actually higher in women treated with metronidazole.

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