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  • Nifedipine (brand name Adalat, Nifedical, and Procardia) is a dihydropyridine calcium channel blocker.
  • Nifedipine is a high blood pressure (hypertension) and migraine medication taken as a daily pill.
  • Nifedipine belongs to a class of drugs known as calcium channel blockers (CCBs).
  • Nifedipine comes as a capsule and an extended-release tablet (long-acting) to take by mouth.
  • It is a yellow crystalline powder.


  • In wet spherical agglomeration (WSA) process the nifedipine particles were agglomerated by dropping a chloroform solution containing a bridging liquid.
  • In spherical crystallization(SC) process the nifedipine microspheres were prepared by pouring a 56C acetone solution containing 0.5% nifedipine into 100 mL 25C water.
  • Differential scanning calorimetry(DSC) showed no change occurred during preparation of the nifedipine microspheres.
  • The nifedipine GITS formulation provides a once-daily dosing regimen with a continuous and slow release of the drug into the intestinal tract, resulting in a smooth plasma concentration/time profile.


  • Nifedipine is used sometimes to treat migraine headaches, Raynaud's syndrome, congestive heart failure, and cardiomyopathy.
  • Nifedipine is used as a coronary vasodilator and an antianginal in the treatment of coronary insufficiency and angina of effort.
  • 0.5% nifedipine ointment is used in healing acute anal fissue and preventing its progress to chronicity.
  • The main function of Nifedipine is vascular dilation associated with a decrease in peripheral resistance and blood pressure.
  • Nifedipine is a type II calcium channel antagonist, which inhibits the influx of calcium ions into myometrial and other cells and thereby reduces muscle contractility.
  • Nifedipine was more successful in arresting preterm labor with less side effects and better tolerability as compared to ritodrine.


  • The conformation of nifedipine, a cardiac and smooth muscle calcium ion channel antagonist is studied in a hydrated bilayer of forty nine l,2-di-myristoyl-sn-glycero-3-phosphorylcholine (DMPC) molecules using molecular dynamics (MD) simulation technique.
  • NADH fluorophotography technique used in the study of nifedipine combined with reperfusion in experimental myocardial infarction.
  • The influence of Nifedipine anf captropill on liver blood flow can be investigated using echo-doppler technique.
  • The applicability of Gas-Liquid Chromatography technique is to measure plasma nifedipine concentrations.

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