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Information @ a Glance

General

  • Paracetamol (INN) or acetaminophen (USAN) is a widely-used analgesic and antipyretic.
  • Paracetamol has been in use as an analgesic for home medication for over 30 years.
  • The effectiveness of paracetamol was discovered without knowing how it works.

Mechanism

  • The proposed mechanism for an interaction between paracetamol use and asthma, depletion of glutathione in lung tissue, was criticised as 'biologically implausible'
  • Paracetamol is primarily metabolised by the liver.
  • Paracetamol and its two primary metabolites are remarkably safe compounds, and the hepatotoxicity of paracetamol arises only through the 5% that is oxidised.
  • Paracetamol manufacture via Nitro Benzene route is yet to start in the country.

Uses

  • Paracetamol has not been shown to cause asthma and remains the analgesic of choice for people with asthma.
  • Paracetamol relieves pain and fever in adults and children, and is the most widely accepted medicine in the UK for this purpose.
  • Paracetamol can be combined with decongestant ingredients to help relieve the symptoms of the common cold, influenza and sinusitis by relieving headache, general aches, nasal congestion and fever.
  • Paracetamol may protect against cardiovascular disease.

Market

  • The total world market for Paracetamol bulk drug is estimated to be about 1,10,000 tonnes per annum, with Europe and North America accounting for nearly 40% of the total market.

  • USA, Germany, Turkey, China and India are the leading producers of Paracetamol bulk drug.

  • The domestic market for paracetamol has grown substantially in the last decade.

  • Exports of paracetamol is likely to grow at an average annual growth rate of 15% considering the tremendous scope that exists for export of paracetamol.

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