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Information @ a Glance

General

  • Peptides (from the Greek πεπτος, "digestible") are the family of short molecules formed from the linking, in a defined order, of various α-amino acids.
  • Proteins are polypeptide molecules.
  • Peptide solubility is dependent on the amino acid content of the peptide.
  • Most peptides are stable at -20°C indefinitely, especially if they are lyophilized and stored in a dessicator.
  • BNP, B-type Natriuretic Peptide is a 32 amino acid polypeptide initially found in brain but later found abundant in cardiac ventricle tissues.

Production Process

  • The peptide is present in large amounts in milk, and PTHrP mRNA has been shown to be present in high amounts in lactating mammary gland.

  • Free amino acids are undoubtedly the least expensive components with which peptide synthesis is performed.

  • Endogenous antimicrobial peptides (AMPs) are small amino acid–based molecules that have the capacity to kill microbes and are produced by the host organism.

  • Glucagon-like peptide-1 (GLP-1) and glucagon share a common precursor, preproglucagon, which upon tissue-specific processing leads to production of GLP-1 in the intestine and glucagon in the pancreas.

Synthesis

  • The Peptide Synthesis Service provides a complete range of services including cleavage, HPLC purification, quality assurance analysis and a variety of amino acid derivatization/labeling techniques.

  • Oligopeptides are synthesized with an Applied Biosystems Model 430A instrument using FMOC based chemistry and uronium salt type activation methodologies

  • Fluorous chemistry is the first new orthogonal phase available for peptide synthesis

  • Solid phase peptide synthesis consists of assembling amino acids from the C-terminal to the N-terminal.

Application & Technology

  • Synthetic peptides have a wide variety of uses ranging from structure-function analysis of sites within a protein, binding assays, receptor agonists/antagonists, to immunogens for the production of antisera.

  • BNP prevents cardiac fibrosis during the pathologic remodeling after cardiac injury.

  • Copper peptides and the lipo-peptide, are both used in cosmeceuticals to stimulate collagen production and promote elasticity.

  • Peptides act as “messengers” from the brain to the body, telling nerves and muscles to perform various functions.

  • The technology relates to a peptide immunotherapy approach to modulate the immune response of T-cell epitopes to rhesus (RhD and RhCc/Ee) antigens.

Market

  • Peptides are widely used in creating medicines where the total market size for peptide medicine is estimated to be approximately 10 billion USD.
  • High technology barriers and limited number of players make the generic peptide drug market an attractive opportunity for Indian players.
  • The U.S. holds 65% of the worldwide therapeutic peptides market, Parmar says. Europe is 30% of the total, with Germany and the U.K. in the lead. Japan dominates activity in Asia.
  • Peptides used in drug formulation and clinical trials account for nearly 93 per cent of the European therapeutic peptides market with R&D comprising the remainder.

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