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Contents on the CD Rom

  • Calcitonin is a 32 amino acid polypeptide hormone that is produced in humans primarily by the Parafollicular (also known as C) cells of the thyroid, and in many other animals in the ultimobranchial body. It acts to reduce blood calcium Ca2+, opposing the effects of parathyroid hormone (PTH). It has been found in fish, reptiles, birds and mammals. Its importance in humans has not been as well established as its importance in other animals.
  • Calcitonin is formed by the proteolytic cleavage of a larger prepropeptide which is the product of the CALC1 gene (CALCA). The CALC1 gene belongs to a superfamily of related protein hormone precursors including islet amyloid precursor protein, calcitonin gene-related peptide, and the precursor of adrenomedullin. The hormone participates in calcium (Ca2+) and phosphorus metabolism. In many ways, calcitonin has the counter effects of parathyroid hormone (PTH).
  • Oral calcitonin may have a chondroprotective role in osteoarthritis (OA), according to data in rats presented last month at the 10th World Congress of the Osteoarthritis Research Society International (OARSI) in Boston, Massachusetts. Unlike several other potential disease-modifying OA drugs, calcitonin also has a “unique analgesic effect on bone pain, which might relieve at least in part symptoms accompanying joint disease,” says Dr. Karsdal, adding that this may be an important factor influencing future drug compliance.
  • This medication is used to treat certain bone problems (e.g., Paget's disease, postmenopausal osteoporosis) and to reduce high blood levels of calcium. Calcitonin is a man-made hormone that works by slowing bone loss and maintaining normal calcium levels in the blood. It may also help to reduce bone pain in people who have Paget's disease.
  • A joint venture between US-based Unigene Laboratories and China's Shijiazhuang Pharmaceutical Group will begin selling injectable calcitonin in China for the treatment of osteoporosis as of 1 April. China is the single largest osteoporosis market with an estimated 90 million sufferers and more than 15 million fractures per year, the company claimed. According to the Shanghai Medical Journal and Chinese medical experts, 90 per cent of Chinese citizens over 60, and virtually all of those over 70, have the disease. The Chinese government has identified osteoporosis as one of the top three health priorities in China. 
  • Unigene's net loss for the three months ended March 31, 2007 was $244,000, or $.00 per share, compared to a net loss of $3,243,000, or $.04 per share for the three months ended March 31, 2006.The three months ended March 31, 2007 and 2006 includes $393,000 and $165,000, respectively, in expenses for non-cash stock optio compensation. As of March 31, 2007, Unigene had approximately $697,000 in expenses for non-cash stock option compensation that remains to be recognized, primarily over the next 12 months. 
  • US pharmaceutical company Upsher-Smith Laboratories has been forced into staffing cuts and a restructuring exercise by delays in the US Food and Drug Administration's review of its nasal calcitonin product for osteoporosis. Upsher-Smith licensed the product, called Fortical, from nasal drug delivery specialist Unigene in 2002. This $10 million (€8.3m) agreement gave Upsher-Smith exclusive US rights to distribute and sell the finished product, with Unigene retaining manufacturing rights. 
  • An oral formulation of salmon calcitonin based on Emisphere Technologies' eligen delivery system has entered Phase III clinical trials for the treatment of osteoarthritis. According to Emisphere, the system has been used for oral delivery of a range of molecules varying in size from 500 Daltons to more than 150,000 Daltons. Oral formulations created with the eligen technology include tablets, solutions and capsules; Emisphere believes it is also applicable to controlled-release dosage forms. 
  • Miacalcic is registered in 97 countries around the world and it is estimated that it has been administered for over 3 million patient years since it was first launched in 1974 in an injectable form. Miacalcic Nasal Spray received its first approval in 1987. Its first European Union marketing licence for post-menopausal osteoporosis was obtained in Portugal in 1987, followed by subsequent approvals in other countries.
  • The osteoporosis pharmaceutical market is currently $7 billion and is expected to grow to $14 billion by 2011. According to IMS, a market research firm, worldwide sales of an existing Calcitonin-Salmon Nasal Spray were approximately $389 million in 2003, of which the U.S. accounts for an estimated $240 million. 
General Information
  • Calcitonin 
  • Calcitonin: Discovery and Early Development
  • Calcitonin - Concentrated and Prediluted Polyclonal Antibody
  • Calcitonin Information

Extraction and Purification

  • Oral Delivery and Recombinant Production of Peptide Hormones
  • A Non-calcitonin Secretory Peptide Derived from Preprocalcitonin
  • New Calcitonin Isolated from the Ray
  • Immunoreactive Calcitonin Production by a Human Promyelocytic Leukemia Cell Line HL60
  • Purification of Calcitonin-Like Peptides from Rat Brain and Pituitary 
  • The Actions of Calcitonin on the TM3 Leydig Cell Line and on Rat Leydig Cell-Enriched Cultures
  • Vascular and Renal Actions of Salmon Calcitonin in Freshwater and Seawater Adapted European Eels
  • Calcitonin Bone Formation: a Knockout Full of Surprise
  • Characterization of rat calcitonin mRNA
  • Calcitonin, an enigmatic hormone
  • Isolation, Structure, Synthesis, and Activity of a New Member of the Calcitonin Gene-related Peptide Family from Frog Skin and Molecular Cloning of Its Precursor 
  • Calcitonin Gene-Related Peptide Rapidly Downregulates Nicotinic Receptor Function and Slowly Raises Intracellular Ca21 in Rat Chromaffin Cells In Vitro 
  • Salmon Calcitonin-Induced Stimulation  
  • Calcium intake by rats: influence of parathyroid hormone, calcitonin, and 1,25-dihydroxyvitamin D 
  • Characterization of the Human Calcitonin Gene-Related Peptide Receptor Subtypes Associated with Receptor Activity-Modifying Proteins 

Company Profiles

  • AnaSpec
  • Bachem
  • Bam Biotech Co Ltd
  • Nastech Pharmaceutical Company
  • Unigene
  • Upsher-Smith Laboratories, Inc


  • Andrew Lawrence Frelinger III, Ph.D.
  • David C. Yeomans, PhD
  • Intota
  • Graham Young
  • John P. Lenihan, MD
  • Peter Petrusz
  • William Y.W.AU, M.D


  • Procedure for preparing salmon calcitonin
  • S-sulfonated calcitonin derivatives 
  • Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
  • Use of calcitonin in osteoarthritis
  • Stabilized calcitonin pharmaceutical composition 
  • Human calcitonin receptor polypeptides 
  • Use of calcitonin and calcitonin-like peptides to treat and prevent multiple sclerosis
  • Intranasal calcitonin formulations 
  • Calcitonin analogue and use thereof 
  • Synthetic calcitonin peptides 


  • Expression and Localization of Prohormone Convertase PC1 in the Calcitonin-producing Cells of the Bullfrog Ultimobranchial Gland 
  • Calcitonin Is a Progesterone Regulated Marker That Forecasts the Receptive State of Endometrium during Implantation 
  • Purification of a functional competitive antagonist for calcitonin gene related peptide action from sardine hydrolysates 
  • Calcitonin Gene-Related Peptide Immunoreactivity in the Spinal Cord of Man and Eight Other Species
  • Recent Developments in Intranasal Drug Delivery Technology are  Creating New Vistas for Peptide and Protein Therapeutics 
  • Enhanced Bioavailability of Calcitonin Formulated with Alkylglycosides following Nasal and Ocular Administration in Rats 
Material Safety Data Sheet
  • Thyroid ELISA Kits
  • Calcitonin Gene-Related Peptide CGRP Receptor
  • Mouse Monoclonal Antibody
  • Rabbit Anti-Calcitonin Gene Related Peptide Polyclonal Antibody
  • Double Antibody Calcitonin
  • Calcitonin In-vitro Diagnostic Test Kit
  • Immulite Calcitonin Control Module
  • Peptide-affinity Purified Polyclonal Antibody to Calcitonin Receptor



  • The role of calcitonin for fracture pain 
  • Calcitonin Inj Uses
  • Meta-Analysis of Calcitonin for the Treatment of Postmenopausal Osteoporosis 
  • A Randomized Trial of Nasal Spray Salmon Calcitonin in Postmenopausal Women with Established Osteoporosis 
  • Use of Calcitonin To Treat Phantom Limb Pain
  • Osteoporosis management in day-to-day practice. The role of calcitonin 
  • Nanomedicines for Overcoming Biological Barriers: Nanoparticles as Carriers for Intestinal Drug Absorption
  • Calcitonin gene-related peptide-induced suppression of luteinizing hormone pulses in the rat 


  • Calcitonin Related Peptides
  • Injectable Salmon Calcitonin
  • Calcitonin Receptor
  • Calcitonin related polypeptide, beta
  • Calcitonin Products List
  • Calcitonin & Calcitonin Receptors/Related Products


  • Market Penetration Ananlysis
  • The Women's Health Resource Center
  • Unigene JV launches calcitonin in China
  • Efficacy of calcitonin in treatment of post-menopausal osteoporosis confirmed by European regulatory authority
  • FDA accepts ANDA filing for Calcitonin-Salmon Nasal Spray
  • Nasal calcitonin delay hits Upsher-Smith Labs
  • Formulary Reclassification Calcitonin Nasal Spray 
  • Novartis receives European marketing authorization for Aclasta
  • Oral calcitonin into Phase III for osteoarthritis
  • Awakening the Silent Osteoporosis Market
  • Unigene Announces Strong Increase in Revenue and Improved Quarterly Income for First Quarter 2007


  • Calcitonin Enzyme-Linked ImmunoSorbent Assay
  • Calcitonin is expressed in the chicken pituitary gland
  • Role of Calcitonin Gene-Related Peptide in the Postischemic Anti-inflammatory Effects of Antecedent Ethanol Ingestion
  • Calcitonin: characterisation and expression in a teleost fish, Fugu rubripes 
  • Calcitonin Test
  • Effects of pertussis toxin on adenylate cyclase responses to prostaglandin E2 and calcitonin in human breast cancer cells 
  • Immunoreactive Substance P and Calcitonin gene Related Peptide in Rat Milk and in Human Milk and Infant Formulas
  • Peptidome project: Analysis of peptides in pig and mouse brain for the Peptidome database 


  • Chinese Suppliers for Calcitonin salmon
  • China Suppliers of Calcitonin
  • Indian Suppliers of Calcitonin
  • Selling Leads of Calcitonin
  • Foreign Exporters & Manufacturers
  • Calcitonin Suppliers 
  • Calcitonin (Salmon) Manufacturers
  • Exporters of Calcitonin
  • Sellers of Calcitonin
  • Calcitonin Manufacturers


  • Foreign Importers & Buyers of Calcitonin
  • Buying Leads of Calcitonin
  • Calcitonin Buyers List

Equipments Suppliers

  • Diagnostic Systems Laboratories
  • Calcitonin RIA kit
  • Calcitonin Control Slide Suppliers
  • Modern Laboratory Services
  • Calcitonin ris Kit Suppliers Directory

Safety and Guides

  • Therapeutic or Pharmacological Classification
  • Calcitonin-Salmon (rDNA origin) Nasal Spray For Intranasal
  • Miacalcin - Calcitonin - Dosage - Side Effects - Drug Interactions
  • Frequently asked Questions about Calcitonin Salmon Injection

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