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  • A protease is any enzyme that conducts proteolysis, that is, begins protein catabolism by hydrolysis of the peptide bonds that link amino acids together in the polypeptide chain.
  • Proteases occur naturally in all organisms and constitute 1-5% of the gene content.
  • Proteases are also a type of exotoxin, which is a virulence factor in bacteria pathogenesis. Bacteria exotoxic proteases destroy extracellular structures.
  • Protease is the digestive enzyme needed to digest protein.


  • Production of protease is done by a local wild-type strain, Aspergillus terreus IMI 282743 using pre-filtered palm oil mill effluent.
  • Protease is produced by submerged cultivation and Solid state cultivation.


  • Microbial proteases, which play a specific catalytic role in the hydrolysis of protein, are indeed one of the most important groups of industrial enzymes and account for about 60% of the total worldwide enzyme sales.


  • Alkaline proteases are extensively used in detergents, leather processing, silver recovery, medical purposes, food processing, feeds and chemical industries as well as waste treatment.
  • Proteases regulate many biological pathways in humans and are components of several bacterial toxins.

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