Resveratrol is a phytoalexin produced naturally by several plants when
under attack by pathogens such as bacteria or fungi.
Resveratrol has also been produced by chemical synthesis, and is sold as
a nutritional supplement derived primarily from Japanese knotweed.
Resveratrol is found in grapes, wine, grape juice, and berries of
Vaccinum species including blueberries, bilberries, and cranberries.
Resveratrol’s full chemical name is 3,4',5-trihydroxystilbene and its
chemical formula is C14H12O3, It has cis and trans isomers.
Resveratrol belongs to a class of polyphenolic compounds called
Resveratrol is a phytoalexin whose synthesis occurs in grapes, and in
consequence, it can be found in grape products such as wine and musts
Resveratrol contained in plasma was purified by solid-phase extraction
using a C18 cartridge.
plants, resveratrol is produced as a branch from the phenylpropanoid
pathway. It is derived from p-coumaric acid, which is an intermediate in
formation of resveratrol was followed by HPLC analysis of 5-ml samples
during the growth of the culture.
is commercially available and procedures for the purification of the
commercial material (by recrystallization from ethanol/water) have been
added to the food starting in early adulthood and caused a dose-dependent
increase of median and maximum lifespan.
resveratrol delays the age-dependent decay of locomotor activity and
cognitive performances and reduces the expression of neurofibrillary
degeneration in the brain.
Many studies have
demonstrated that this molecule exhibits a wide range of biological and
pharmacological activities both in vitro and in vivo.
(trans-3,5,4˘-trihydroxystilbene), a phenolic compound present in grapes,
wines, and peanuts, has been reported to have health benefits including
anticarcinogenic effects and protection against cardiovascular diseases.
The formation of
resveratrol was followed by HPLC analysis of 5-ml samples during the
growth of the culture.
been found to inhibit the proliferation of a variety of human cancer cell
lines, including those from breast, prostate, stomach, colon, pancreatic,
and thyroid cancers when added to cells cultured outside the body.
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