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General
  • Resveratrol is a phytoalexin produced naturally by several plants when under attack by pathogens such as bacteria or fungi.
  • Resveratrol has also been produced by chemical synthesis, and is sold as a nutritional supplement derived primarily from Japanese knotweed.
  • Resveratrol is found in grapes, wine, grape juice, and berries of Vaccinum species including blueberries, bilberries, and cranberries.
  • Resveratrol’s full chemical name is 3,4',5-trihydroxystilbene and its chemical formula is C14H12O3, It has cis and trans isomers. 
  • Resveratrol belongs to a class of polyphenolic compounds called stilbenes.

Process

  • Resveratrol is a phytoalexin whose synthesis occurs in grapes, and in consequence, it can be found in grape products such as wine and musts and by-products.
  • Resveratrol contained in plasma was purified by solid-phase extraction using a C18 cartridge.
  • In plants, resveratrol is produced as a branch from the phenylpropanoid pathway. It is derived from p-coumaric acid, which is an intermediate in lignin production.
  • The formation of resveratrol was followed by HPLC analysis of 5-ml samples during the growth of the culture.

Report

  • Trans-resveratrol is commercially available and procedures for the purification of the commercial material (by recrystallization from ethanol/water) have been developed.

  • Resveratrol was added to the food starting in early adulthood and caused a dose-dependent increase of median and maximum lifespan.

  • In addition, resveratrol delays the age-dependent decay of locomotor activity and cognitive performances and reduces the expression of neurofibrillary degeneration in the brain.

  • Many studies have demonstrated that this molecule exhibits a wide range of biological and pharmacological activities both in vitro and in vivo.

Application

  • Trans-Resveratrol (trans-3,5,4˘-trihydroxystilbene), a phenolic compound present in grapes, wines, and peanuts, has been reported to have health benefits including anticarcinogenic effects and protection against cardiovascular diseases.

  • The formation of resveratrol was followed by HPLC analysis of 5-ml samples during the growth of the culture.

  • Resveratrol has been found to inhibit the proliferation of a variety of human cancer cell lines, including those from breast, prostate, stomach, colon, pancreatic, and thyroid cancers when added to cells cultured outside the body.

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