General
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Resveratrol is a phytoalexin produced naturally by several plants when
under attack by pathogens such as bacteria or fungi.
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Resveratrol has also been produced by chemical synthesis, and is sold as
a nutritional supplement derived primarily from Japanese knotweed.
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Resveratrol is found in grapes, wine, grape juice, and berries of
Vaccinum species including blueberries, bilberries, and cranberries.
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Resveratrol’s full chemical name is 3,4',5-trihydroxystilbene and its
chemical formula is C14H12O3, It has cis and trans isomers.
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Resveratrol belongs to a class of polyphenolic compounds called
stilbenes.
Process
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Resveratrol is a phytoalexin whose synthesis occurs in grapes, and in
consequence, it can be found in grape products such as wine and musts
and by-products.
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Resveratrol contained in plasma was purified by solid-phase extraction
using a C18 cartridge.
- In
plants, resveratrol is produced as a branch from the phenylpropanoid
pathway. It is derived from p-coumaric acid, which is an intermediate in
lignin production.
- The
formation of resveratrol was followed by HPLC analysis of 5-ml samples
during the growth of the culture.
Report
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Trans-resveratrol
is commercially available and procedures for the purification of the
commercial material (by recrystallization from ethanol/water) have been
developed.
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Resveratrol was
added to the food starting in early adulthood and caused a dose-dependent
increase of median and maximum lifespan.
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In addition,
resveratrol delays the age-dependent decay of locomotor activity and
cognitive performances and reduces the expression of neurofibrillary
degeneration in the brain.
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Many studies have
demonstrated that this molecule exhibits a wide range of biological and
pharmacological activities both in vitro and in vivo.
Application
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Trans-Resveratrol
(trans-3,5,4¢-trihydroxystilbene), a phenolic compound present in grapes,
wines, and peanuts, has been reported to have health benefits including
anticarcinogenic effects and protection against cardiovascular diseases.
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The formation of
resveratrol was followed by HPLC analysis of 5-ml samples during the
growth of the culture.
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Resveratrol has
been found to inhibit the proliferation of a variety of human cancer cell
lines, including those from breast, prostate, stomach, colon, pancreatic,
and thyroid cancers when added to cells cultured outside the body.
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