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Information @ a Glance

General

  • Streptomycin is an antibiotic drug.
  • It is derived from the actinobacterium Streptomyces griseus.
  • Streptomycin is an antibiotic that inhibits both gram positive and gram negative bacteria.
  • Streptomycin is a water-soluble aminoglycoside.

Biosynthesis

  • Streptomyces strains isolated from soil were found to possess various numbers of genes from the streptomycin biosynthesis cluster.
  • Protein involved in the synthesis of streptomycin.
  • Myo-inositol, especially in combination with arginine, enhances streptomycin production.
  • The biosynthesis of streptomycin in Streptomyces griseus has been studied by adding D-[3,4-14C2]glucose or D-t1,3-14C2]glucose to the growth medium and degrading the streptomycin produced.

Application

  • Streptomycin is applied as a potential control treatment for walnut blight.
  • Streptomycin is purified from the fermentation of the actinomycete Streptomyces griseus and used in a variety of pharmaceutical applications.
  • Streptomycin has an effect on arrhythmias induced by an increase of ventricular wall stress in the rat heart.
  • A commercial source of streptomycin has been used to induce seedlessness in the seeded grape cultivar Rubi (Italia Red).

Market

  • Samples of Chinese honey and blended honey containing Chinese honey tested positive for Chloramphenicol and Streptomycin, antibiotics used in human medicine.
  • India, today, is a major producer of streptomycin. (Production has almost stopped in all the major developed countries). Indigenous demand is fully met from indigenous supply.
  • Estimated demand matrix may be generated for each drug especially for streptomycin and rifampicin.

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