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  • Sucralfate is an oral gastrointestinal medication primarily indicated for the treatment of active duodenal ulcers. It is also used for the treatment of gastroesophageal reflux disease and stress ulcers.
  • sucralfate is a sucrose sulfate-aluminium complex that binds to the hydrochloric acid in the stomach and acts like an acid buffer with cytoprotective properties.
  • Sucralfate is a locally acting substance that in an acidic environment (pH < 4), reacts with hydrochloric acid in the stomach to form a cross-linking, viscous, paste-like material capable of acting as an acid buffer for as long as 6 to 8 hours after a single dose.
  • It also attaches to proteins on the surface of ulcers, such as albumin and fibrinogen, to form stable insoluble complexes.
  • Sucralfate has been used in the treatment of oral, esophageal, gastric and duodenal ulcers. It has also been employed to prevent drug-induced (e.g., aspirin) gas­tric erosions.
  • Sucralfate may be used in any condition associated with stomach ulceration. Common examples include: toxin ingestion, kidney failure, liver failure, certain forms of cancer, and megaesophagus . It is also often given with medications that are associated with stomach ulceration

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